Fig. 4
From: Angiotensin-(1–7) attenuates organ injury and mortality in rats with polymicrobial sepsis
Effects of angiotensin-(1–7) on biochemical parameters in rats that underwent cecal ligation and puncture. These parameters include (a) lactate dehydrogenase, (b) alanine aminotransferase (ALT), (c) blood urea nitrogen, (d) creatinine (CRE), and (e) blood glucose during the experimental period. Rats underwent sham operation (SOP, n = 6), SOP plus angiotensin-(1–7) administration (1 mg/kg at 3 and 6 h after SOP procedure [SOP-Ad], n = 6), cecal ligation and puncture (CLP, n = 8), CLP plus angiotensin-(1–7) administration (1 mg/kg at 3 h after CLP procedure [CLP-As], n = 3), and CLP plus angiotensin-(1–7) administration (1 mg/kg at 3 and 6 h after CLP procedure [CLP-Ad], n = 8). Owing to blood clots or kinking of the arterial catheter, blood samples could not be obtained in some of rats surviving the whole experimental period. Analysis of variance for repeated measures was used for analysis of time × group interaction. Data are shown as median and IQR. **p < 0.01, ***p < 0.001 CLP. vs. SOP; #p < 0.05, ##p < 0.01 CLP + As or CLP + Ad vs. CLP