Outcomes | Anticipated absolute effects (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Certainty of the evidence (GRADE) | |
---|---|---|---|---|---|
Risk with control | Risk with carbonic anhydrase | ||||
Duration of hospital stay (days) | The mean duration of hospital stay in the intervention group was 0.42 days more (4.82 fewer to 5.66 more) | – | 117 (2 RCTs) | ⨁⨁◯◯ LOWa | |
Duration of mechanical ventilation (h) | The mean duration of mechanical ventilation in the intervention group was 27.09 h lower (50.11 lower to 4.08 lower) | – | 427 (2 RCTs) | ⨁⨁◯◯ LOWb,c | |
Mortality | 130 per 1000 | 122 per 1000 (74 to 202) | RR 0.94 (0.57 to 1.56) | 427 (2 RCTs) | ⨁⨁◯◯ LOWa |
Adverse events | 78 per 1000 | 133 per 1000 (76 to 232) | RR 1.71 (0.98 to 2.99) | 508 (5 RCTs) | ⨁⨁⨁◯ MODERATEa |