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Table 1 Patient characteristics

From: Factors associated with recurrence and mortality in central line-associated bloodstream infections: a retrospective cohort study

Characteristics

Complete cases (N = 366)

Patients with 60-day mortality or recurrence (N = 81)

Patients with 60-day recurrence-free survival (N = 285)

P valuea

Age (years)

55 (40–64)

59 (48–65)

53 (38–63)

0.005

Male

225 (61.5)

48 (59.3)

177 (62.1)

0.64

Hospital length of stay prior to CLABSI (days)

12 (6–18)

12 (6–19)

11 (6–18)

0.70

In ICU at CLABSI diagnosis

119 (32.5)

32 (39.5)

87 (30.5)

0.13

Immunosuppressionb

136 (37.2)

31 (38.3)

105 (36.8)

0.81

End-stage renal disease

19 (5.2)

7 (8.6)

12 (4.2)

0.15

Cirrhosis

14 (3.8)

7 (8.6)

7 (2.5)

0.02

Diabetes mellitus

106 (29.0)

26 (32.1)

80 (28.1)

0.48

Shockc

50 (13.7)

16 (19.8)

34 (11.9)

0.07

Invasive mechanical ventilationd

89 (24.3)

23 (28.4)

66 (23.2)

0.33

SOFA score

6 (4–8)

6 (4–9)

5 (3–7)

0.002

Causative organisme

 Staphylococcus aureus

49 (13.4)

10 (12.4)

39 (13.7)

0.75

 Methicillin-resistant Staphylococcus aureus

32 (8.7)

7 (8.6)

25 (8.8)

0.97

 Coagulase-negative Staphylococcus

60 (16.4)

12 (14.8)

48 (16.8)

0.66

 Enterococcus species

81 (22.1)

19 (23.5)

62 (21.8)

0.74

 Gram-negative bacilli

125 (34.2)

25 (30.9)

100 (35.1)

0.48

 Pseudomonas species

18 (4.9)

5 (6.2)

13 (4.6)

0.56

 Other bacteria

49 (13.4)

8 (9.9)

41 (14.4)

0.29

 Fungi

41 (11.2)

13 (16.1)

28 (9.8)

0.12

 Candida species

37 (10.1)

12 (14.8)

25 (8.8)

0.11

 Polymicrobial

49 (13.4)

10 (12.4)

39 (13.7)

0.75

 High-risk organismf

104 (28.4)

27 (33.3)

77 (27.0)

0.27

All central lines removedg

272 (74.3)

51 (63.0)

221 (77.5)

0.008

Days until central lines removedh

1 (0–2)

1 (0.5–2)

1 (0–2)

0.18

Antimicrobial treatment duration (days)

15 (10–20)

11 (4–18)

15 (12–20)

<  0.001

  1. Values are presented as number (percentage) or median (interquartile range) as appropriate
  2. CLABSI central line-associated bloodstream infection, ICU intensive care unit, SOFA Sequential Organ Failure Assessment
  3. aUnivariate analyses were performed with Mann-Whitney U tests for continuous variables and Chi-square or Fisher’s exact tests for categorical variables
  4. bOne hundred and twenty patients were neutropenic (absolute neutrophil count less than 500 cells/mm3), 26 were organ transplant patients on immunosuppression, and 2 had human immunodeficiency virus infection with a CD4 count less than 200 cells/mm3
  5. cDefined as the receipt of any vasoactive medication on the date of CLABSI diagnosis
  6. dDefined as the receipt of any invasive mechanical ventilation on the date of CLABSI diagnosis
  7. ePatients could have multiple causative organisms; numbers may not add up to 100%
  8. fPrespecified as Staphylococcus aureus, Pseudomonas species, and Candida species
  9. gDefined as patients with all causative central lines removed within 4 days of CLABSI diagnosis
  10. hN = 272 for complete cases; n = 51 for patients with 60-day mortality or recurrence; n = 221 for patients with 60-day recurrence-free survival
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Critical Care

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