Impact of a remifentanil supply shortage on mechanical ventilation in a tertiary care hospital: a retrospective comparison

Table 2 Regression models of outcome parameters

Model	Coefficient	RR	95% CI	Pr(>\|z\|)
Primary outcome: Invasive mechanical ventilation hours^a
Group only	Intercept	74.46	73.05–75.89	<0.001*
Group only	Shortage group	2.19	2.14–2.24	<0.001*
Confounder	Intercept	20.89	19.39–22.49	<0.001*
	Shortage group	1.47	1.43–1.51	<0.001*
	Age	0.99	0.99–0.99	<0.001*
	Sex, female	1.08	1.06–1.11	<0.001*
	BMI^§	1.019	1.016 -1.021	<0.001*
	SAPS III^§	0.996	0.995–0.997	<0.001*
	SOFA_max	1.114	1.109–1.118	<0.001*
	Prim. tracheostomy	1.18	1.11–1.26	<0.001*
	Sec. tracheostomy	5.68	5.52–5.84	<0.001*
	COPD	0.85	0.81–0.88	<0.001*
	Intracranial OP/TBI	1.61	1.56–1.66	<0.001*
	Coma	0.99	0.95–1.03	0.522
	Delirium	1.18	1.13–1.19	<0.001*
Secondary outcome: Length of ICU stay, days^a
Group only	Intercept	8.93	8.45–9.43	<0.001*
Group only	Shortage group	1.55	1.45–1.67	<0.001*
Secondary outcome: Days with non-invasive ventilation, days^a
Group only	Intercept	1.84	1.62–2.08	<0.001*
Group only	Shortage group	0.27	0.21–0.35	<0.001*
Secondary outcome: Length of hospital stay, days^a
Group only	Intercept	33.04	32.10–33.99	<0.001*
Group only	Shortage group	1.40	1.35–1.46	<0.001*
Secondary outcome: Occurrence of pneumonia^b
Group only	Intercept	0.13	0.08–0.20	<0.001*
Group only	Shortage group	1.84	1.04–3.35	0.040
Secondary outcome: Occurrence of sepsis^b
Group only	Intercept	0.09	0.05–0.14	<0.001*
Group only	Shortage group	1.96	0.99–4.09	0.061

Abbreviations: BMI body mass index, CI confidence interval, COPD chronic obstructive pulmonary disease, ICU intensive care unit, OP/TBI intracranial operation/traumatic brain injury, RR risk ratio, SAPS III Simplified Acute Physiology Score III, SOFA Sequential/Sepsis-related Organ Failure Assessment
Statistical methods: ^aPoisson count regression model. ^bLogistic regression model. *Significant
^§For clearer readability, the third decimal place was added

ISSN: 1364-8535