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Table 3 Multivariate analysis of the in-hospital mortality and prognostic scoring system at day 2 (n = 248)

From: An early increase in endothelial protein C receptor is associated with excess mortality in pneumococcal pneumonia with septic shock in the ICU

Prognostic markers Logistic regression Scoring system
Odds ratio P value 95% CI Weight
sEPCR log at day 1 (ng/mL) 1.95 0.0407 [1.03–3.70] 0.289
delta sEPCR (day 2 - day 1, ng/mL) 1.01 0.0323 [1.00–1.03] 0.269
Age (years) 1.03 0.0586 [1.00–1.05] 0.293
McCabe score at day 1 0.52 0.1833 [0.19–1.37] −0.014
Gender, male versus female 2.02 0.0586 [0.97–4.19] 0.384
Fine’s score (log) 2.94 0.1928 [0.73–11.8] 0.341
SOFA score at day 1 (square) 1.01 0.0199 [1.00–1.01] 0.441
SAPS II 1.02 0.2136 [0.99–1.04] 0.257
  1. The scoring system and the multivariate analysis were based on least absolute shrinkage and selection operator (lasso) logistic regression. The prognostic score was the sum of the product between the weights and the normalized explicative variables
  2. sEPCR soluble endothelial protein C receptor, SOFA Sepsis-related Organ Failure Assessment, SAPS Simplified Acute Physiology Score