Synbiotics modulate gut microbiota and reduce enteritis and ventilator-associated pneumonia in patients with sepsis: a randomized controlled trial

Table 3 Serial changes in fecal organic acids in the Synbiotics and No-Synbiotics groups

	Initial		1 week		2 weeks		p value
	No-Synbiotics	Synbiotics	No-Synbiotics	Synbiotics	No-Synbiotics	Synbiotics	Group	Week	Group×week
Total organic acids	44.2 ± 11.5	49.1 ± 12.1	46.2 ± 12	116.6 ± 12.1^a	54.8 ± 12.6	71.4 ± 12.6	0.169	0.161	0.664
Succinic acid	0.1 ± 12.4	0.8 ± 12.4	3.4 ± 13	1.4 ± 12.4	49.1 ± 13.7	1.1 ± 13.7	0.335	0.078	0.091
Lactic acid	2.6 ± 5.0	4.4 ± 5.2	1.3 ± 5.1	16.9 ± 5.2	7.4 ± 5.3	13.1 ± 5.4	0.287	0.089	0.565
Formic acid	5.5 ± 4.4	13.4 ± 4.6	6.5 ± 4.5	10.4 ± 4.6	4.4 ± 4.7	6.9 ± 4.7	0.370	0.391	0.465
Acetic acid	33.9 ± 7.6	22.5 ± 8.0	25.8 ± 7.9	61.0 ± 8.0^a	23.5 ± 8.2	41.6 ± 8.3	0.901	0.506	0.058
Propionic acid	1.3 ± 2.6	2.5 ± 2.7	5.8 ± 2.7	9.1 ± 2.7	4.7 ± 2.9	3.2 ± 2.9	0.491	0.414	0.625
Butyric acid	0.3 ± 3.4	4.8 ± 3.6	1.8 ± 3.5	17.1 ± 3.6	0.2 ± 3.6	3.9 ± 3.6	0.642	0.731	0.722

Values are mean ± SE (μmol/g feces)
p value by linear mixed effects model
^aStatistical significance between groups determined with Bonferroni’s correction

ISSN: 1364-8535