Liberal versus conservative oxygen therapy in critically ill patients: using the fragility index to determine robust results

Table 1 Fragility index calculated for the study included in the systematic review and meta-analysis by Chu et al. [1]

Study	Setting	Liberal group (FiO2 0.52 CI:0.39-0.85)	Conservative group (FiO2 0.21 CI:0.21-0.50)	p value for mortality in each study	Fragility index n (p)
Ali et al. (2014) [6]	Stroke	5/155	4/146	0.99	0 (1)
Roffe et al. (2017) [7]	Stroke	50/2668	45/2668	0.75	0 (0.506)
Ronning et al. (1999) [8]	Stroke	36/292	27/258	0.54	0 (0.506)
Singhal et al. (2005) [9]	Stroke	0/9	1/7	NS	0 (0.438)
NCT00414726	Stroke	14/43	4/42	0.08	2 (0.072)
Shi et al. (2017) [10]	Stroke	0/9	0/9	NS	0 (1)
NCT02378454 (2015)	Sepsis	3/25	2/25	NS	0 (1)
Butler et al. (1987) [11]	Limb ischemia	1/17	0/22	NS	0 (0.436)
Schietroma et al. (2016) [12]	Perforated peptic ulcer	2/119	4/120	0.42	0 (0648)
NCT02687217	Acute appendicitis	0/30	0/30	NS	0 (1)
Girardis et al. (2016) [5]	Critical illness	80/243	58/235	0.01	0 (0.055)
Panwar et al. (2016) [13]	Critical illness	12/51	13/53	0.44	0 (1)
Hofmann et al. (2017) [14]	Myocardial infarction	53/3311	44/3318	0.08	0 (0.359)
Khoshnood et al. (2015) [15]	Myocardial infarction	3/85	3/75	NS	0 (1)
Kuisma et al. (2006) [16]	Cardiac arrest	4/14	4/14	NS	0 (1)
Rawles et al. (1976) [17]	Myocardial infarction	9/105	3/95	NS	0 (0.140)
Stub et al. (2012) [18]	Myocardial infarction	5/132	11/132	NS	0 (0.204)
Ukholkina et al. (2005) [19]	Myocardial infarction	1/58	0/79	NS	0 (0.428)
Young et al. (2014) [20]	Cardiac arrest	5/9	4/8	NS	0 (1)