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Table 1 Fragility index calculated for the study included in the systematic review and meta-analysis by Chu et al. [1]

From: Liberal versus conservative oxygen therapy in critically ill patients: using the fragility index to determine robust results

Study Setting Liberal group (FiO2 0.52 CI:0.39-0.85) Conservative group (FiO2 0.21 CI:0.21-0.50) p value for mortality in each study Fragility index n (p)
Ali et al. (2014) [6] Stroke 5/155 4/146 0.99 0 (1)
Roffe et al. (2017) [7] Stroke 50/2668 45/2668 0.75 0 (0.506)
Ronning et al. (1999) [8] Stroke 36/292 27/258 0.54 0 (0.506)
Singhal et al. (2005) [9] Stroke 0/9 1/7 NS 0 (0.438)
NCT00414726 Stroke 14/43 4/42 0.08 2 (0.072)
Shi et al. (2017) [10] Stroke 0/9 0/9 NS 0 (1)
NCT02378454 (2015) Sepsis 3/25 2/25 NS 0 (1)
Butler et al. (1987) [11] Limb ischemia 1/17 0/22 NS 0 (0.436)
Schietroma et al. (2016) [12] Perforated peptic ulcer 2/119 4/120 0.42 0 (0648)
NCT02687217 Acute appendicitis 0/30 0/30 NS 0 (1)
Girardis et al. (2016) [5] Critical illness 80/243 58/235 0.01 0 (0.055)
Panwar et al. (2016) [13] Critical illness 12/51 13/53 0.44 0 (1)
Hofmann et al. (2017) [14] Myocardial infarction 53/3311 44/3318 0.08 0 (0.359)
Khoshnood et al. (2015) [15] Myocardial infarction 3/85 3/75 NS 0 (1)
Kuisma et al. (2006) [16] Cardiac arrest 4/14 4/14 NS 0 (1)
Rawles et al. (1976) [17] Myocardial infarction 9/105 3/95 NS 0 (0.140)
Stub et al. (2012) [18] Myocardial infarction 5/132 11/132 NS 0 (0.204)
Ukholkina et al. (2005) [19] Myocardial infarction 1/58 0/79 NS 0 (0.428)
Young et al. (2014) [20] Cardiac arrest 5/9 4/8 NS 0 (1)
  1. NS not significant