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Table 2 Multivariate analysis by Cox regression to adjust prognostic scores with confounders associated with 28-day mortality

From: Validation of CLIF-C ACLF score to define a threshold for futility of intensive care support for patients with acute-on-chronic liver failure

MELD score Child-Pugh score CLIF-C ACLF score
Parameter HR p Value Parameter HR p Value Parameter HR p Value
MELD score 1.05 (95% CI 1.03–1.07) < 0.0001 Child-Pugh score 1.35 (95% CI 1.20–1.53) < 0.0001 CLIF-C ACLF score 1.07 (95% CI 1.05–1.09) < 0.0001
Age (years) 1.01 (95% CI 1.00–1.03) 0.12 Age (years) 1.02 (95% CI 1.00–1.04) 0.04    
Albumin (g/L) 0.98 (95% CI 0.95–1.01) 0.17     Albumin (g/L) 0.99 (95% CI 0.96–1.02) 0.41
Platelet count (109/L) 0.97 (95% CI 0.99–1.00) 0.04 Platelet count (109/L) 1.00 (95% CI 0.99–1.00) 0.07 Platelet count (109/L) 0.99 (95% CI 0.99–1.00) 0.002
HE (0–2/3–4) 1.31 (95% CI 0.80–2.15) 0.29       
  1. Abbreviations: ACLF Acute-on-Chronic Liver Failure, CLIF European Foundation for the study of chronic liver failure, HE Hepatic encephalopathy, MELD Model for End-Stage Liver Disease