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Table 1 Baseline characteristics of patients

From: Functional outcomes in adults with tuberculous meningitis admitted to the ICU: a multicenter cohort study

Variable

Missing, n

All patients

(n = 90)

Good outcome

(n = 35)

Poor outcome

(n = 55)

p value

Clinical features

 Age (years)

0

43 (29; 58)

33 (24; 55)

45 (34; 58)

0.04

 Male sex

0

56 (62.2)

19 (54.3)

37 (67.3)

0.27

 Immunosuppression

0

41 (45.6)

12 (34.3)

29 (52.7)

0.13

 Knaus C/D

0

6 (6.7)

1 (2.9)

5 (9.1)

0.40

 MRC gradea

0

   

0.06

  1

 

3 (3.3)

2 (5.7)

1 (1.8)

 

  2

 

26 (28.9)

14 (40)

12 (21.8)

 

  3

 

61 (67.8)

19 (54.3)

42 (76.4)

 

 GCS score

2

12 (8; 14)

14 (10; 14)

9 (7; 13)

< 0.01

 Major focal deficit

0

41 (45.6)

10 (28.6)

31 (56.4)

0.02

 Meningeal syndrome

0

55 (61.1)

24 (68.6)

31 (56.4)

0.28

 Cranial nerve palsies

0

24 (26.7)

9 (25.7)

15 (27.3)

1.00

 Seizures

0

31 (34.4)

9 (25.7)

22 (40)

0.18

 Extraneurological signs

0

62 (68.9)

21 (60)

41 (74.5)

0.17

 Temperature (°C)

0

38 (37; 39)

38 (37.5; 39)

38 (36.9; 39)

0.53

Laboratory findings

 Serum sodium level (mmol/L)

2

131 (127; 135)

133 (128; 137)

130 (127; 134)

0.35

 CSF pleocytosis (cells/μl)b

3

130 (27; 300)

140 (36; 350)

120.5 (27; 250)

0.56

 CSF lymphocyte (%)b

18

73.2 (37; 94)

88.6 (57.1; 96.8)

59 (33.3; 90)

0.04

 CSF glucose level (mmol/L)b

3

2 (1.1; 3)

2.2 (1.6; 2.6)

1.9 (1; 3.3)

0.71

 CSF protein level (g/L)b

4

1.9 (1; 3)

1.5 (1.2; 1.9)

2.3 (0.9; 3.5)

0.07

Brain CT Infarction

1

83 (93.3)

32 (94.1)

51 (92.7)

1.00

 Infarction

0

12 (14.5)

0 (0)

12 (23.5)

< 0.01

 Hydrocephalus

0

16 (19.3)

2 (6.3)

14 (27.5)

0.02

 Abscess/tuberculoma

0

19 (22.9)

9 (28.1)

10 (19.6)

0.43

 Basal arachnoiditis

0

4 (4.8)

0 (0)

4 (7.8)

0.16

Brain MRI

0

75 (83.3)

29 (82.9)

46 (83.6)

1.00

 Infarction

0

38 (50.7)

9 (31)

29 (63)

< 0.01

 Hydrocephalus

0

25 (33.3)

4 (13.8)

21 (45.7)

< 0.01

 Abscess/tuberculoma

0

35 (46.7)

13 (44.8)

22 (47.8)

0.82

 Basal arachnoiditis

0

37 (49.3)

13 (44.8)

24 (52.2)

0.64

  1. Data presented as median (interquartile range) or number (percentage)
  2. MRC British Medical Research Council, GCS Glasgow Coma Scale, CSF cerebrospinal fluid, CT computed tomography, MRI magnetic resonance imaging
  3. aGrade 3 indicates a GCS score ≤ 10
  4. bData available for 87 patients