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Table 2 Pharmacokinetic/pharmacodynamic parameters at inclusion in 106 patients

From: Predictors of insufficient peak amikacin concentration in critically ill patients on extracorporeal membrane oxygenation

Variable

Valuea

Weight at time of Cmax, kg

80.0 (71.0; 97.5)

Amikacin dose, mg

2000 (1750; 2500)

Amikacin regimen, mg/kg

25.0 (24.0; 25.5)

Amikacin Cmax, mg/L

65.8 (51.8; 82.4)

Patients with Cmax < 60 mg/L

41 (39)

Patients with Cmax > 80 mg/L

27 (25)

ICU admission-to-Cmin interval, h

24.1 (23.4; 24.8)

Amikacin Cmin, mg/L

7.25 (3.60; 13.60)

Patients with Cmin < 2.5 mg/Lb

24 (28)

  1. Cmax peak serum concentration, Cmin trough serum concentration
  2. aValues are expressed as median (1st; 3rd quartile]) or number (percentage)
  3. bAvailable for 85 patients
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Critical Care

ISSN: 1364-8535