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Table 3 Multivariate logistic analyses of predictors of AKI

From: Predicting acute kidney injury using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic peptide levels in patients treated at medical cardiac intensive care units

Variables

Multivariate model 1

Multivariate model 2

OR (95% CI)

P value

OR (95% CI)

P value

Age (per 10 years increment)

1.15 (0.98–1.37)

0.09

1.16 (0.98–1.37)

0.08

Hypertension

1.42 (0.97–2.10)

0.07

1.33 (0.91–1.94)

0.14

Diabetes mellitus

1.31 (0.90–1.91)

0.16

1.26 (0.87–1.83)

0.22

Acute decompensated heart failure

1.26 (0.81–1.96)

0.30

1.47 (0.96–2.25)

0.08

Mechanical ventilation before admission

1.24 (0.47–3.27)

0.67

1.30 (0.51–3.30)

0.58

IABP before admission

2.49 (1.41–4.42)

0.002

2.48 (1.40–4.37)

0.002

Heart rate (per 10 beats per minute increment)

1.01 (0.94–1.08)

0.82

1.02 (0.95–1.09)

0.54

White blood cell count (per ×103/μL increment)

1.04 (0.99–1.09)

0.17

1.04 (0.99–1.09)

0.11

Hemoglobin (g/dL) (per 1 g/dL increment)

0.94 (0.87–1.02)

0.14

0.94 (0.87–1.02)

0.13

eGFR (per 10 mL/min/1.73m2 increment)

0.91 (0.83–0.99)

0.03

0.85 (0.78–0.92)

< 0.001

Glucose (per 10 mg/dL increment)

1.02 (0.99–1.04)

0.20

1.02 (1.00–1.05)

0.10

hs-CRP (per 10-fold increment)

1.06 (0.85–1.34)

0.60

1.15 (0.92–1.44)

0.21

NT-proBNP (per 10-fold increment)

1.58 (1.14–2.19)

0.006

  

Tertile of NT-proBNP (pg/mL)

 First (< 425)

  

1.0

 

 Second (425–2730)

  

1.79 (0.98–3.25)

0.06

 Third (> 2730)

  

1.97 (1.19–3.26)

0.009

hs-TnT (per 10-fold increment)

0.96 (0.78–1.18)

0.67

1.02 (0.83–1.24)

0.88

Urinary L-FABP (per 10-fold increment)

2.66 (2.03–3.48)

< 0.001

  

Tertile of Urinary L-FABP (ng/mL)

 First (< 3.3)

  

1.0

 

 Second (3.3–11.5)

  

1.42 (0.87–2.30)

0.16

 Third (> 11.5)

  

3.40 (2.13–5.44)

< 0.001

LVEF (per 10% increment)

1.12 (0.98–1.29)

0.11

1.11 (0.96–1.27)

0.15

Diuretics

0.98 (0.68–1.49)

0.98

0.93 (0.64–1.37)

0.71

  1. Multivariate model adjusted for all baseline variables with p < 0.05 on univariate analysis. NT-proBNP and L-FABP levels were assessed as either continuous variables (model 1) or variables categorized into tertiles (model 2)
  2. AKI acute kidney injury, OR odds ratio, CI confidence interval, IABP intraaortic balloon pump, eGFR creatinine-based estimated glomerular filtration rate, hs-CRP high-sensitivity C-reactive protein, NT-proBNP N-terminal pro-B-type natriuretic peptide, hs-TnT high-sensitivity cardiac troponin T, L-FABP liver-type fatty acid-binding protein, LVEF left ventricular ejection fraction
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Critical Care

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