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Table 2 Studies analysing the potential association between PLT storage duration and clinical or transfusion outcomes in haematology or oncology patients

From: Platelet storage duration and its clinical and transfusion outcomes: a systematic review

Study Population Study design PLT characteristics and maximum storage duration Primary outcome Secondary outcome Analysis/comparator Main results
Van Rhenen et al. [35] Haematology
Prophylactic PLTs
103 patients
Propsective observational study for the review outcomea Leucoreduced WBD, buffy coat derived
5 days
1-h CCI 24-h CCI Up to 5 days Association between PLT storage time and 1 and 24-h CCI
Dijkstra-Tiekstra et al. [28] Haematology
Prophylactic PLTs
70 patients, 389 transfusions
Prospective observational single centre Leucoreduced, WBD, buffy coat derived
7 days
1-h CI ≥ 10
1-h CCI ≥ 7.5
1-h CCI 2, 3, 4, 5, 6 and 7 days No difference between 5 and 7 days of storage; PLTs stored for 2 days had higher 1-h CCI than PLTs stored for 7 days
Slichter et al. [12] Haematology
528 patients Prophylactic transfusion
Post hoc analysis of a randomised trial Apheresis and WBD, plasma rich preparation
5 days
1- and 24-h CCI Time to next transfusion
Refractoriness
2, 3, 4 and 5 days Analysis per transfusion PLTs stored less than 48 h were associated with better 1- and 24-h CCI and s longer time to next transfusion
Akkok et al. [31] Haematology
77 patients
Prophylactic and therapeutic transfusions
Prospective observational, two-centre Leucoreduced
Apheresis and WBD, buffy coat derived
6.5 days
1-h CCI 18–24 h CCI
Time to next transfusion
Up to 6.5 days Decrease in 1- and 24-h CCI and time to next transfusion when storage time increased
Heim et al. [36] Haematology
672 patients Prophylactic transfusion
Prospective observational Apheresis
5 days
1- and 24-h CCI TRAE Up to 5 days PLTs stored for ≥ 3 days were associated with a lower CCI
Diedrich et al. [27] Haematology
60 patients
Prophylactic transfusion
Double blind randomised, single centre Leucoreduced
Blood group O irradiated WBD, buffy coat derived
7 days
1- and 24-h CCI Time to next PLT transfusion
Bleeding
Storage duration:1 to 5 days versus 6 to 7 days
Mean storage 2.9 days vs 6.6 days
Higher CCI and longer time to next transfusion in the group “fresher PLT”
Kerkhoffs et al. [32] Haemato-oncology
278 patients
Prospective multicentre observational study for the review outcomesa Leucoreduced, WBD, buffy coat derived
7 days
1-h CCI 24-h CCI RBC number
Bleeding
Time to next transfusion
Up to 7 days Storage time was associated with 1- and 24-h CCI but not with bleeding
Triulzi et al. [34] Haematology
1231 patients
Post hoc analysis of a multicentre RCT Apheresis or WBD plasma rich preparation
Leucoreduced
5 days
Clinical bleeding (time from first transfusion to first ≥ grade 2 bleeding) Absolute PLT
CI and CCI 4, 16 and 24 h
Age of PLTs of the first transfusion No association between PLT storage duration and bleeding
PLTs stored for ≤ 3 days were associated with higher CCI and PLT CI
Heuft et al. [33] Haematology
77 patients
526 prophylactic transfusions
Retrospective single centre Apheresis PLTs
5 days
24-h CCI Time to next transfusion
RBC number
Bleeding
Max 4 days versus 3 days
Subgroup with only one transfusion/day, without RBC transfusion
Fresher PLTs were associated with higher CCI and less bleeding
Dijkstra-Tiekstra et al. [29] Onco-haematology
93 patients with only one PLT/day
389 transfusions
Prospective observational, three-centre WBD, buffy coat derived
7 days
1- and 24-h CCI 2, 3, 4, 5, 6, 7 days No association
MacLennan et al., [26] Haematology
122 patients
Crossover blocked randomised trial; 2 to 5 days versus 5 to 7 days Apheresis and WBD buffy coat derived, leucoreduced
7 days
CCI > 4.5 between 8 to 24 h CCI
Time to next transfusion
Bleeding events (WHO classification)
Mean age 3.8 days (SD1.0) versus 6.4 (0.5) days No effect of the age of PLTs on primary outcome and bleeding
Kaufman et al. [4] Haematology
1102 patients, 5034 transfusions
Post hoc analysis of a multicentre RCT Apheresis or WBD plasma rich preparation, leukoreduced
5 days
TRAE TRAE considered separately 0–2 days, 3 days, 4 days versus 5 days as reference No association
Kaplan et al. [30] Haematology
146 patients, 242 transfusions
Retrospective single centre study WBD riboflavin based PRTs
7 days
24-h PLT CI TRAE Up to 5 days versus 6–7 days No association
  1. Abbreviations: CCI corrected count increment, WBD whole blood derived, RCT randomised controlled trial, PAS platelet additive solution, PLT platelet, PLT CI, platelet count increment, PRT pathogen reduction technology, SD standard deviation, TRAE transfusion-related adverse events, WHO World Health Organisation
  2. aThese studies are randomised trials, but randomisation was not performed by PLT storage duration; therefore, they are considered as observational studies