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Table 2 Characteristics of included observational studies

From: Left ventricular systolic function evaluated by strain echocardiography and relationship with mortality in patients with severe sepsis or septic shock: a systematic review and meta-analysis

Author, year

population (number)

Echocardiography timing

GLS software and TTE views used

Data reported

SAPS

SOFA

APACHE

MV

Mortality

Longest follow up

Boissier, 2017

78 ICU patients with septic shock

TTE within 24 h of ICU admission

Philips’ Qlab 8.1 (Philips®)

Ap: 4ch, 2ch

GLS and LVEF

60.1 ± 20.5

11.7 ± 3.4

-

84.6%

43.6%

Hospital

Chang, 2015

111 ICU patients with septic shock

TTE within 24 h of ICU admission

EchoPAC

v. BT09 (GE®)

Ap: 4ch, 2ch, 3ch

GLS and LVEF

-

-

21 ± 8

65.8%

35.1%

Hospital

De Geer, 2014

50 ICU patients with septic shock

TTE within 24 h of ICU admission

EchoPac

v. 112 (GE®)

Ap: 4ch, 2ch, 3ch

GLS and LVEF

-

11 (9–12)

-

84%

34%

90-day

Innocenti, 2016

56 ED patients with septic shock

TTE within 24 h if ICU admission

Philips’ Qlab 8.1 (Philips®)

Ap: 4ch, 2ch

GLS and LVEF

-

6.3 ± 2.8

-

–

27.2%

28-day

Landesberg, 2014

106 ICU patients with severe sepsis or septic shock

TTE on ICU admission day or as soon as possible

Philips’ Qlab 8.1 (Philips®)

Ap: 4ch, 2ch

GLS and LVEF

-

-

21.61 ± 6.8

100%

39%

Hospital

Lanspa, 2017

298 ICU patients with severe sepsis or septic shock

TTE within 24 h of ICU admission

Image-Arena platform (TomTec®)

Ap: 4ch

GLS

-

9 (6–12)

25 (18–23)

–

23%

28-day

Orde, 2014

60 adult patients with severe sepsis or septic shock

TTE within 24 h of meeting severe sepsis criteria

Syngo Velocity Vector Imaging

(Siemens®)

Ap: 4ch, 2ch, 3ch

GLS and LVEF

-

11 ± 4

-

65%

48%

180-day

Shahul, 2015*

35 ICU patients with sepsis and septic shock

TTE on admission and at 24 h post

cardiac perf.

Analysis v1.1 (TomTec®)

Ap: 4ch

GLS and LVEF

-

6 (2.1–9)

21.7 ± 6.2

69%

23.3%

30-day

  1. Data on the number of patients on mechanical ventilation (MV) are reported, if available, at the time of echocardiographic assessment. Severity scores are provided according to the version reported by each study. Severity scores are reported according to the version of scoring adopted by the authors. Software used for global longitudinal strain (GLS) assessment are abbreviated for ease of reading
  2. ED Emergency Department, ICU Intensive Care Unit, LVEF left ventricular ejection fraction, TTE trans-thoracic echocardiography, Ap apical view, 4ch four-chamber view, 2ch two-chamber view, 3ch three-chamber view, SAPS simplified acute physiology score, SOFA sequential organ failure assessment, APACHE acute physiology and chronic health evaluation
  3. *In this study we obtained data from the 35 patients with septic shock, while the remaining 15 patients with sepsis were excluded