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Table 2 Breathing pattern and gas exchange in different experimental conditions

From: High-flow nasal cannula oxygen therapy decreases postextubation neuroventilatory drive and work of breathing in patients with chronic obstructive pulmonary disease

 

HFNC1

Conventional O2

HFNC2

RR (breaths/min)

20.5 ± 2.9

21.4 ± 4

20.0 ± 1.9

TiNEUR (s)

0.92 ± 0.21

0.95 ± 0.22

0.92 ± 0.17

pH

7.45 ± 0.07

7.44 ± 0.08

7.46 ± 0.08

PaCO2 (mmHg)

49.9 ± 11.9

51.8 ± 12.7

50.1 ± 12.6

HCO3 (mEq/L)

30.9 ± 7.6

31.3 ± 7.8

31.4 ± 8.4

PaO2 (mmHg)

75.1 ± 6.9

72.9 ± 8.6

81.2 ± 8

Applied FiO2a

0.46 ± 10

0.80 ± 0.19b,c

0.46 ± 0.12

  1. Data are expressed as mean ± standard deviation
  2. Conventional O2 conventional low flow oxygen therapy through a nonocclusive face mask, FiO2 inspiratory oxygen fraction, HFNC high-flow nasal cannula oxygen therapy, PaCO2 arterial partial carbon dioxide pressure, PaO2 arterial partial oxygen pressure, RR respiratory rate, TiNEUR neural inspiratory time
  3. a The FiO2 delivered during conventional O2 therapy is overestimated since the patient’s inspiratory flow was higher than the mask flow (10 L/min) and, therefore, the difference between patient inspiratory flow and mask flow was taken by room air; this makes inappropriate any comparison between the PaO2/FiO2 ratio in the different experimental conditions
  4. b Different from HFNC1, ANOVA, with Bonferroni correction
  5. c Different from HFNC2, ANOVA, with Bonferroni correction