Early application of continuous high-volume haemofiltration can reduce sepsis and improve the prognosis of patients with severe burns

Table 3 Outcomes of patients in high-volume haemofiltration and control groups in per-protocol analysis

	Burn ≥ 50% TBSA			Burn ≥ 80% TBSA
	Control (n = 36)	HVHF (n = 36)	p Value	Control (n = 17)	HVHF (n = 16)	p Value
Mortality
28-day, n (%)	9 (25.0)	5 (13.9)	0.37	7 (41.2)	4 (25.0)	0.46
60-day, n (%)	13 (36.1)	6 (16.7)	0.11	10 (58.8)	4 (25.0)	0.08
90-day, n (%)	15 (41.7)	6 (16.7)^a	0.04	11 (64.7)	4 (25.0)^a	0.04
Sepsis, n (%)	19 (52.8)	10 (27.8)	0.05	13 (76.5)	6 (37.5)^a	0.04
Septic shock, n (%)	16 (44.4)	5 (13.9)^a	0.01	11 (64.7)	3 (18.8)^a	0.01
Duration of MV (days)	9.5 (7.0, 11.8)	7.0 (5.0, 10.0)	0.06	10.0 (7.0, 18.0)	7.0 (2.0, 8.0)^a	0.03
ICU days	30.0 (20.5, 48.8)	34.0 (15.5, 53.0)	0.70	31.0 (24.5, 54.0)	51.5 (22.3, 78.3)	0.26
Duration of vasopressors (days)	4.0 (2.0, 11.3)	1.0 (1.0, 2.0)^a	0.005	2.0 (4.0, 11.3)	1.0 (1.0, 2.0)^a	0.005

Abbreviations: TBSA Total burn surface area, MV Mechanical ventilation, ICU Intensive care unit, HVHF High-volume haemofiltration
Data are presented as mean ± SD, median (25th and 75th quantiles) or percentages. Patients with complete data were included in outcomes comparison via the per-protocol analysis
^a p < 0.05 indicates a significant difference compared with the control group

ISSN: 1364-8535