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Table 7 Selected list of medications associated with lower seizure threshold [113]

From: Antiepileptic drugs in critically ill patients

Antibiotics Psychotropic agents Analgesics Neurostimulants Miscellaneous agents
Cefepime Bupropion Meperidineb Amantadine Baclofen
Erythromycin Haloperidol Tramadol Amphetamines Flumazenil
Imipenema Phenothiazines   Bromocriptine  
Isoniazid SSRIs    
Levofloxacin TCAs    
Linezolid     
Meropenem     
Metronidazole     
Penicillins     
  1. SSRI selective serotonin reuptake inhibitor, TCA tricyclic antidepressant
  2. aCarbapenems have been reported to have the highest rate of seizure among all drugs
  3. bNormeperidine, the active metabolite of meperidine, has been associated with seizures and accumulates in renal failure