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Table 7 Selected list of medications associated with lower seizure threshold [113]

From: Antiepileptic drugs in critically ill patients

Antibiotics

Psychotropic agents

Analgesics

Neurostimulants

Miscellaneous agents

Cefepime

Bupropion

Meperidineb

Amantadine

Baclofen

Erythromycin

Haloperidol

Tramadol

Amphetamines

Flumazenil

Imipenema

Phenothiazines

 

Bromocriptine

 

Isoniazid

SSRIs

   

Levofloxacin

TCAs

   

Linezolid

    

Meropenem

    

Metronidazole

    

Penicillins

    
  1. SSRI selective serotonin reuptake inhibitor, TCA tricyclic antidepressant
  2. aCarbapenems have been reported to have the highest rate of seizure among all drugs
  3. bNormeperidine, the active metabolite of meperidine, has been associated with seizures and accumulates in renal failure
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Critical Care

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