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Table 1 Baseline characteristics of children admitted with community-acquired sepsis to PICU

From: Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS)

 

All patients (n = 795)

29 days–12 months (n = 261)

1–5 years (n = 278)

5–12 years (n = 151)

12–18 years (n = 105)

P

Sex (male n, %)

428 (54%)

151 (58%)

148 (53%)

76 (50%)

53 (51%)

ns

Age

2 years (8 months–6 years)

5 months (2–8 months)

2 years (18 months–3 years)

8 years (6–10 years)

15 years (14–16 years)

–

Ethnicitya

     

ns

 African/North African

46 (6%)

15 (6%)

12 (4%)

14 (10%)

5 (5%)

 

 Asian

57 (7%)

22 (9%)

18 (7%)

10 (7%)

7 (7%)

 European

607 (79%)

195 (76%)

222 (82%)

106 (75%)

84 (82%)

 Meso/South American

7 (1%)

1 (0%)

3 (1%)

1 (1%)

2 (2%)

 Middle Eastern

10 (1%)

5 (2%)

1 (0%)

2 (1%)

2 (2%)

 Other/mixed

45 (6%)

18 (7%)

15 (6%)

9 (6%)

3 (3%)

Time interval onset symptoms to hospital admissionb (days)

1 (1–3)

1 (0–3)

2 (1–)

2 (0–4)

1 (1–3)

ns

Immunizations up to datec

585 (89%)

177 (82%)

219 (89%)

114 (95%)

75 (97%)

< 0.001

Number of underlying conditions

     

< 0.01

 None

507 (64%)

176 (67%)

192 (69%)

85 (56%)

54 (51%)

 

 1

175 (22%)

55 (21%)

53 (19%)

36 (24%)

31 (30%)

  ≥ 2

113 (14%)

30 (12%)

33 (12%)

30 (20%)

20 (19%)

Underlying conditions

     

< 0.01

 Neurologic and neuromuscular

70 (9%)

6 (2%)

17 (6%)

27 (18%)

20 (19%)

 

 Cardiovascular

52 (7%)

14 (5%)

27 (10%)

8 (5%)

3 (3%)

 Respiratory

40 (5%)

14 (5%)

12 (4%)

9 (6%)

5 (5%)

 Renal and urologic

18 (2%)

5 (2%)

8 (3%)

2 (1%)

3 (3%)

 Gastrointestinal

35 (4%)

9 (3%)

11 (4%)

8 (5%)

7 (7%)

 Hematologic or immunologic

11 (1%)

2 (0%)

4 (1%)

4 (3%)

1 (1%)

 Metabolic

20 (3%)

5 (2%)

6 (2%)

5 (3%)

4 (4%)

 Other congenital or genetic defect

56 (7%)

9 (3%)

18 (6%)

17 (11%)

12 (11%)

 Malignancy

9 (1%)

1 (0%)

1 (0%)

2 (1%)

5 (5%)

 Premature and neonatal

87 (11%)

56 (21%)

19 (7%)

9 (6%)

3 (3%)

 Other

52 (7%)

10 (4%)

16 (6%)

14 (9%)

12 (11%)

Illness severity

 PRISM scored

14 (7–21)

14 (7–22)

15 (8–22)

14 (8–21)

11 (4–16)

< 0.01

 PIM2 scoree (predicted death, %)

4.0 (1.1–9.5)

4.0 (1.0–8.2)

4.8 (1.1–10.3)

4.2 (1.1–17.1)

3.3 (0.9–9.0)

ns

 Lactate at PICU admissionf (mmol/L)

1.8 (1.1–3.4)

1.6 (1.0–3.2)

1.6 (1.0–3.2)

2.2 (1.1–3.7)

2.3 (1.2–4.7)

ns

 Septic shock (n, %)

466 (59%)

133 (51%)

168 (60%)

94 (62%)

71 (68%)

< 0.05

  1. Values are reported as counts (percentages) or medians (interquartile ranges), unless stated otherwise
  2. Abbreviations: PICU pediatric ICU, PRISM Pediatric Risk of Mortality [27], PIM2 Pediatric Index of Mortality 2 [28], ns not significant
  3. aEthnicity data were available for 772/795 patients; 256/261 infants, 271/278 toddlers, 142/151 school-aged children, and 103/105 adolescents
  4. bTime interval from onset of symptoms to hospital admission was available for 642/795 patients; 212/261 infants, 229/278 toddlers, 111/151 school-aged children, and 90/105 adolescents
  5. cImmunization data were available for 657/795 patients; 215/261 infants, 245/278 toddlers, 120/151 school-aged children, and 77/105 adolescents
  6. dPRISM score was available for 672/795 patients; 223/261 infants, 240/278 toddlers, 118/151 school-aged children, and 91/105 adolescents
  7. ePIM2 score was available for 681/795 patients; 224/261 infants, 243/278 toddlers, 123/151 school-aged children, and 91/105 adolescents
  8. fLactate at PICU admission was available for 444/795 patients; 146/261 infants, 167/278 toddlers, 76/151 school-aged children, and 55/105 adolescents
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