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Table 1 Derivation and validation cohort characteristics

From: Development and validation of a pre-hospital “Red Flag” alert for activation of intra-hospital haemorrhage control response in blunt trauma

 

Derivation

Validation

Comparison

SH

(n = 672)

No SH

(n = 3003)

SH

(n = 415)

No SH

(n = 2584)

SH

p

No SH

p

Demography and outcome

 Age (years)

42 ± 19

37 ± 16

44 ± 19

38 ± 17

ns

ns

 Male (%)

465 (69%)

2340 (78%)

312 (75%)

2017 (78%)

0.040

ns

 BMI (kg/m2)

25.3 ± 5

24.7 ± 4.3

25.2 ± 4.4

24.8 ± 4.7

ns

ns

 SAPS II

45 ± 22

21 ± 15

46 ± 23

21 ± 15

ns

ns

 ICU LOS

18 ± 23

8 ± 15

14 ± 19

7 ± 15

0.001

0.001

Hospital mortality

163 (25%)

137 (5%)

93 (23%)

110 (4%)

ns

ns

Predicted mortality by TRISSa (%)

27

6

27

6

Mechanism of injury (all blunt)

 MVA

133 (20%)

765 (26%)

97 (23%)

617 (24%)

  

 Motorbike

151 (23%)

905 (30%)

95 (23%)

861 (33%)

  

 Pedestrian and bicycle

109 (16%)

381 (13%)

47 (11%)

343 (13%)

ns

ns

 Fall

243 (36%)

792 (26%)

144 (35%)

621 (24%)

  

 Miscellaneous

36 (5%)

150 (5%)

32 (8%)

142 (6%)

  

Severity of injuries

 ISS

30 (18–38)

12 (5–20)

27 (14–41)

12 (5–21)

ns

ns

 Head and neck AIS

2 (0–4)

0 (0–3)

1 (0–3)

0 (0–2)

ns

ns

 Thorax AIS

3 (0–3)

0 (0–3)

3 (0–4)

0 (0–3)

ns

ns

 Abdomen AIS

2 (0–3)

0 (0–2)

2 (0–3)

0 (0–2)

ns

ns

 Extremities pelvis AIS

3 (2–3)

2 (0–2)

3 (1–4)

0 (0–3)

ns

0.001

At admission

 Total pre-hospital time (min)

85 ± 39

80 ± 37

80 ± 37

77 ± 34

0.010

ns

 SBP (mmHg)

102 ± 34

129 ± 23

107 ± 35

130 ± 24

ns

ns

 DBP (mmHg)

62 ± 23

76 ± 16

65 ± 24

79 ± 17

ns

0.001

 Haemoglobin (g/dl)

10.2 ± 2.6

13.4 ± 1.7

10.7 ± 2.7

13.5 ± 1.7

0.010

ns

 Lactate (mmol/L)

4.8 ± 3.4

1.9 ± 0.9

4.9 ± 3.4

2 ± 0.9

ns

0.002

 Prothrombin time (%)

57 ± 22

83 ± 15

61 ± 23

84 ± 15

0.010

ns

Surgery day 1

562 (84%)

1867 (62%)

305 (74%)

1235 (48%)

0.001

0.001

Angio-embolization day 1

111 (17%)

67 (2%)

88 (21%)

86 (3%)

0.001

0.001

SH characteristics

 Immediate surgery

123 (16%)

88 (21%)

ns

 Transfusion in trauma room

425 (63%)

245 (59%)

ns

 Lactates > 5 mmol/L

323 (51%)

194 (52%)

ns

 ≥ 4 RBCs in first 6 h

385 (57%)

204 (49%)

0.010

  1. Results expressed as mean ± standard deviation, n (%) or median (1st quartile–3rd quartile)
  2. SH severe haemorrhage, ns not significant, BMI body mass index, SAPS Simplified Acute Physiology Index, ICU LOS intensive care unit length of stay, TRISS Trauma Injury Severity Score, MVA motor vehicle accident, ISS Injury Severity Score, AIS Abbreviated Injury Scale, SBP systolic blood pressure, DBP diastolic blood pressure RBC red blood cell
  3. a TRISS computed by giving a respiratory rate of 20/min in all patients [35]