Table 3 Probability of target attainment (PTA) for micafungin
AUC0–24/MIC of 285 for body weight (kg) equal to: | AUC0–24/MIC of 3000 for body weight (kg) equal to: | AUC0–24/MIC of 5000 for body weight (kg) equal to: | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dose (mg/24 h) | MIC (μg/ml) | 45 | 80 | 115 | 150 | 185 | 45 | 80 | 115 | 150 | 185 | 45 | 80 | 115 | 150 | 185 |
100 | 0.008 | 100 | 100 | 100 | 100 | 100 | 99.0 | 98.9 | 98.8 | 98.5 | 97.8 | 83.7 | 78.4 | 72.3 | 64.0 | 55.1 |
0.016 | 100 | 100 | 100 | 100 | 100 | 72.0 | 58.8 | 52.2 | 40.9 | 31.1 | 9.2 | 3.7 | 1.4 | 0.5 | 0.2 | |
0.032 | 100 | 100 | 100 | 100 | 100 | 23.0 | 0.7 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
0.064 | 99.9 | 99.7 | 99.7 | 99.7 | 99.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
0.125 | 93.8 | 85.6 | 79.0 | 75.8 | 71.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
0.25 | 23.4 | 9.8 | 4.8 | 1.9 | 0.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
0.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
150 | 0.008 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 99.9 | 99.8 | 98.8 | 98.4 | 98.1 | 97.2 | 91.3 |
0.016 | 100 | 100 | 100 | 100 | 100 | 96.7 | 95.5 | 89.6 | 80.8 | 78.6 | 57.3 | 49.2 | 35.4 | 25.3 | 17.6 | |
0.032 | 100 | 100 | 100 | 100 | 100 | 38.5 | 22.2 | 12.3 | 6.9 | 3.0 | 0.9 | 0.1 | 0.1 | 0.0 | 0.0 | |
0.064 | 100 | 100 | 100 | 100 | 100 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
0.125 | 99.1 | 98.9 | 98.9 | 98.6 | 98.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
0.25 | 72.8 | 59.8 | 52.8 | 42.7 | 32.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
0.5 | 2.5 | 0.8 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
200 | 0.008 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 99.7 | 99.7 | 99.6 | 99.4 | 99.1 |
0.016 | 100 | 100 | 100 | 100 | 100 | 99.0 | 98.9 | 98.8 | 98.5 | 97.8 | 83.7 | 78.4 | 72.3 | 64.0 | 55.1 | |
0.032 | 100 | 100 | 100 | 100 | 100 | 72.0 | 58.8 | 52.2 | 40.9 | 31.1 | 9.2 | 3.7 | 1.4 | 0.5 | 0.2 | |
0.064 | 100 | 100 | 100 | 100 | 100 | 2.3 | 0.7 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
0.125 | 99.9 | 99.8 | 99.7 | 99.7 | 99.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
0.25 | 93.8 | 85.6 | 79.0 | 75.8 | 71.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
0.5 | 23.4 | 9.8 | 4.8 | 1.9 | 0.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |