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Table 1 Demographic data of the included patients

From: Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?

Characteristics All patients (N = 24)
Male sex, n (%) 14 (61)
Age, years 53 ± 17
Comorbidities, n (%)
 Arterial hypertension 3 (13)
Diabetes mellitus 5 (21)
 Tobacco use 2 (10)
 Others 3 (13)
Origin of patients, n (%)
 Emergency room 12 (50)
 Ward 5 (21)
 Operating room 7 (29)
Source of sepsis, n (%)
 Lung 7 (28)
 Urinary 5 (21)
 Abdominal 5 (21)
 Other sources 5 (21)
 Undetermined 2 (8)
Hemodynamic data
 Norepinephrine dosage D0, μg/kg/minute 0.3 (0.1–0.5)
 Lactate D0, mg/dl 22 (18–36)
 Mean arterial pressure D0, mmHg 70 (63–78)
Ventilatory data
 Use of mechanical ventilation D0, n (%) 16 (67)
 Tidal volume D0, ml 500 ± 88
 PEEP D0, cmH2O 8 ± 2.7
 Fraction of inspired oxygen 0.4 ± 0.17
 Peripheral oxygen saturation D0, % 96 ± 2
 Duration of mechanical ventilation, days 3 (2.25–7)
Hematologic and inflammatory data
 Leukocytes D0, cells/mm3 18,974 ± 9790
 Leukocytes D7, cells/mm3 13,270 ± 6262
 Hemoglobin D0, g/dl 10.4 ± 1.6
 Hemoglobin D7, g/dl 9.7 ± 1.7
 Platelets D0, 103 cells/mm3 185 ± 134
 Platelets D7, 103 cells/mm3 261 ± 114
 CRP D0 (n = 18), mg/dl 290 (212–327)
 CRP D7 (n = 17), mg/dl 51 (30–125)
 Procalcitonin D0 (n = 9), ng/ml 15.7 (2–22.4)
SAPS3 score 57.7 ± 6.2
SOFA score D0 8.4 ± 3.3
SOFA score D7 1.7 ± 3.8
ICU length of stay, days 5 (4–7.75)
Hospital length of stay, days 13.5 (8–22.5)
Hospital mortality, n (%) 8 (35)
  1. Abbreviations: PEEP Positive end-expiratory pressure, CRP C-reactive protein, SAPS3 Simplified Acute Physiology Score III, SOFA Sequential Organ Failure Assessment, ICU Intensive care unit
  2. Data are expressed as number (%), mean ± SD, or median (25th–75th percentile)