Fig. 4
From: Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury
Ascorbate (Asc) can enter the cerebrospinal fluid (CSF) directly through the choroid plexus via the sodium-dependent vitamin C transporter (SVCT)2. Ascorbate enters the neuron also via SVCT2. This route is a slow, saturable, controlled process. Dehydroascorbate (DHA) is transported directly and fast into the brain via the abundant glucose transporter (GLUT)1 transporters on the endothelial cells of the blood brain-barrier and via the GLUT1 or GLUT3 on the neurons. Inside the neurons, DHA can be reduced back to ascorbate