Table 1 Main characteristics of the randomized and observational studies
Author, year | Study design | Number of centers; country | Study scale, total number (anti/non-anti) | Study population | Definition of antiplatelet therapy | Definition of ARDS |
|---|---|---|---|---|---|---|
Kor, 2016 [18] | RCT | 16; USA | 390 (195/195) | Patients aged 18 years or older with an elevated risk of developing ARDS (LIPS ≥4) | Aspirin | Berlin definition |
Vincent, 1985 [30] | RCT | 1; Belgium | 43 (16/17) | Patients developed an episode of non-cardiogenic shock due to hemorrhage, trauma or sepsis | Dipyridamole | Severe hypoxemia and generalized lung infiltrates with PAWP <14 mmHg |
Mazzeffi, 2015 [32] | Retrospective cohort | 1; USA | 375 (181/194) | Patients received aortic valve replacement surgery with cardiopulmonary bypass | Aspirin | Berlin definition |
Chen, 2015 [31] | Prospective cohort | 1; USA | 1149 (287/862) | Patients admitted to the ICU with a high risk of ARDS | Aspirin | AECC definition |
Valerio, 2013 [11] | Retrospective cohort | 1; USA | 651 (272/379) | Patients admitted to the medical ICU with severe sepsis and septic shock on antiplatelet therapy before diagnosis of severe sepsis or septic shock. | Aspirin, clopidogrel | AECC definition |
Kor, 2011 [33] | Prospective cohort | 20; USA, 2; Turkey | 3855 (976/2879) | Adult, non-surgical patients admitted to the hospital with at least one major risk factor for ALI | Aspirin | AECC definition |
Erlich, 2011 [34] | Retrospective cohort | 1; USA | 161 (79/82) | Adult patients admitted to the ICU with at least one major risk factor for ALI | Aspirin, clopidogrel bisulfate, ticlopidine, hydrochloride, cilostazol, dipyramidole, anagrelide, or persantine | AECC definition |
Ahmed, 2014 [36] | Population-based, nested case-control | 2; USA | 828 (414/414)a | Patients with hospital-acquired ARDS and matched controls | Aspirin, abciximab, cilostazol, clopidogrel,dipyridamole, eptifibatide, ticlopidine | AECC definition |
Tuinman, 2012 [35] | Nested case-control | 1; Netherlands | 218 (109/109)a | Adult patients admitted to the medical-surgical ICU diagnosed with TRALI and matched controls | Aspirin, clopidogrel | The 2004 consensus definition of TRALI |