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Table 2 Outcome data from included studies

From: The efficacy and safety of pre-hospital cooling after out-of-hospital cardiac arrest: a systematic review and meta-analysis

First author, year (site) [reference]

Number of participants (total/I/C)

Survival to discharge (I vs C)

Survival of those with shockable rhythm (I vs C)

Temperature at hospital arrival (I vs C)

Pulmonary oedema (I vs C)

Re-arrest (I vs C)

Mean pre-hospital volume infused (ml)

Favourable neurological outcome (I vs C)

Survival at hospital arrival (I vs C)

Bernard, 2002 (Australia) [6]

77/43/34

21 (49%)

11 (32%)

N/A

N/A

35.0

35.5

N/A

N/A

N/A

N/A

N/A

21 (49%)

9 (26%)

N/A

N/A

Bernard, 2010 (Australia) [17]

234/118/116

56 (47%)

62 (53%)

N/A

N/A

34.6

35.4

0

0

0

0

1900

56 (48%)

61 (53%)

N/A

N/A

Bernard, 2012 (Australia) [18]

163/82/81

11 (13%)

7 (9%)

N/A

N/A

34.4

35.7

0

0

N/A

N/A

1500

10 (12%)

7 (10%)

75 (91%)

74 (91%)

Bernard, 2016 (Australia) [11]

1198/618/580

63 (10%)

66 (11%)

55 (19%)

62 (23%)

34.7

35.4

62 (10%)

26 (45%)

N/A

N/A

1200

63 (10%)

63 (11%)

304 (49%)

317 (55%)

Castren, 2010 (multi-site) [23]

200/96/104

14 (15%)

13 (13%)

10 (37%)

10 (33%)

34.2

35.5

0

0

3 (3%)

2 (2%)

N/A

11 (11%)

9 (9%)

32 (33%)

42 (41%)

Debaty, 2014 (France) [22]

245/123/122

7 (6%)

5 (4%)

N/A

N/A

33.9

35

7 (6%)

8 (7%)

N/A

N/A

1000

7 (6%)

4 (3%)

41 (33%)

36 (30%)

Kamarainen, 2009 (Finland) [21]

37/19/18

11 (58%)

10 (56%)

N/A

N/A

34.1

35.2

0

0

2 (11%)

3 (17%)

2370

8 (42%)

8 (44%)

N/A

N/A

Kim, 2007 (United States) [20]

125/63/62

21 (67%)

18 (71%)

19 (66%)

10 (45%)

34.7

35.7

24 (38%)

27 (44%)

15 (24%)

13 (21%)

1236

19 (30%)

16 (26%)

49 (78%)

48 (77%)

Kim, 2014 (United States) [19]

1359/688/671

259 (38%)

249 (37%)

183 (63%)

187 (64%)

34.8

35.8

256 (37%)

184 (27%)

176 (26%)

138 (21%)

1435

231 (34%)

225 (33%)

679 (99%)

660 (98%)

Scales, 2017 (Canada) [12]

582/279/303

92 (33%)

98 (31%)

79 (64%)

74 (55%)

35.1

35.2

33 (12%)

54 (18%)

21 (8%)

25 (8%)

640

82 (29%)

76 (26%)

250 (90%)

258 (85%)

  1. I Intervention (pre-hospital therapeutic hypothermia), C Comparator
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