Table 2 GRADE evidence profile of outcomes, tight glucose control vs usual glucose control

Hospital mortality

4021 (6 studies)

0.95 (0.62–1.45)

3 fewer per 1000 (from 20 fewer to 23 more)

⊕ ⊕ ⊕⊝ moderate^b

Critical

Severe hypoglycemia (glucose < 40 ml/dl)

3835 (5 studies)

4.11 (2.67–6.32)

42 more per 1000 (from 23 more to 69 more)^b

⊕ ⊕ ⊕ ⊕ high

Critical

Any hypoglycemia (glucose < 60 mg/dl)

3747 (4 studies)

4.57 (2.24–9.33)

157 more per 1000 (from 61 more to 299 more)

⊕ ⊕ ⊕ ⊕ high^b

Critical

Dialysis

3049 (3 studies)

0.63 (0.45–0.86)

24 fewer per 1000 (from 9 fewer to 36 fewer)

⊕ ⊕ ⊕ ⊕ high^b

Important

Seizures

3047 (3 studies)

0.98 (0.59–1.63)

0 fewer per 1000 (from 8 fewer to 12 more)

⊕ ⊕ ⊝⊝ low^b,c

Important

Sepsis

4021 (6 studies)

0.83 (0.63–1.08)

20 fewer per 1000 (from 45 fewer to 9 more)

⊕ ⊕ ⊕ ⊕ high

Important