Neuromuscular blockade is associated with the attenuation of biomarkers of epithelial and endothelial injury in patients with moderate-to-severe acute respiratory distress syndrome

Table 3 Change in biomarker concentration per day of NMB in a multivariable linear regression model

Group	Change in SP-D per day of NMB			Change in VWF per day of NMB			Change in IL-8 per day of NMB
Group	Estimate	95% CI	P value	Estimate	95% CI	P value	Estimate	95% CI	P value
P/F < 120 + LTVV	−23.7	−44.8, −2.5	0.028	−33.5	−60.5, −6.4	0.015	−362.6	−689.3, −35.9	0.030
P/F < 120 + HTVV	34.1	10.4, 57.7	0.005	8.9	−21.5, 39.2	0.566	92.7	−273.1, 458.5	0.619
P/F > 120 + LTVV	14.6	−11.9, 41.0	0.279	11.2	−22.6, 45.0	0.517	−84.7	−492.5, 323.0	0.683
P/F > 120 + HTVV	72.3	44.6, 99.9	< 0.001	53.5	18.1, 88.9	0.003	−370.6	−56.3, 797.5	0.089

CI confidence interval, IL interleukin, LTVV low tidal volume ventilation, LTVV low tidal volume ventilation, NMB neuromuscular blockade, P/F arterial oxygen tension/fractional inspired oxygen, SP-D surfactant protein D, VWF von Willebrand factor

ISSN: 1364-8535