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Table 3 Change in biomarker concentration per day of NMB in a multivariable linear regression model

From: Neuromuscular blockade is associated with the attenuation of biomarkers of epithelial and endothelial injury in patients with moderate-to-severe acute respiratory distress syndrome

Group Change in SP-D per day of NMB Change in VWF per day of NMB Change in IL-8 per day of NMB
Estimate 95% CI P value Estimate 95% CI P value Estimate 95% CI P value
P/F < 120 + LTVV −23.7 −44.8, −2.5 0.028 −33.5 −60.5, −6.4 0.015 −362.6 −689.3, −35.9 0.030
P/F < 120 + HTVV 34.1 10.4, 57.7 0.005 8.9 −21.5, 39.2 0.566 92.7 −273.1, 458.5 0.619
P/F > 120 + LTVV 14.6 −11.9, 41.0 0.279 11.2 −22.6, 45.0 0.517 −84.7 −492.5, 323.0 0.683
P/F > 120 + HTVV 72.3 44.6, 99.9 < 0.001 53.5 18.1, 88.9 0.003 −370.6 −56.3, 797.5 0.089
  1. CI confidence interval, IL interleukin, LTVV low tidal volume ventilation, LTVV low tidal volume ventilation, NMB neuromuscular blockade, P/F arterial oxygen tension/fractional inspired oxygen, SP-D surfactant protein D, VWF von Willebrand factor