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Table 1 Demographics

From: Leukocyte telomere length in paediatric critical illness: effect of early parenteral nutrition

 

Total population

Subgroup with neutrophil count available

Matched subgroupsa

Baseline characteristics

PICU patients

N = 1148

PICU patients

N = 644

PICU patients

N = 326

Healthy children

N = 326

Male sex, N (%)

640 (55.7)

355 (55.1)

180 (55.2)

179 (54.9)

Age (years)

1.8 (0.3–7.4)

1.6 (0.3–5.9)

4.5 (1.7–8.7)

4.5 (1.8–7.8)

Age <1 year, N (%)

476 (41.5)

276 (42.9)

51 (15.6)

44 (13.5)

Height (%)b

38.7 (8.5–78.2)

35.1 (7.8–71.5)

38.1 (8.5–78.4)

 

Weight (%)b

32.5 (8.3–67.8)

29.8 (6.5–62.2)

39.8 (14.8–70.0)

 

Chronicity, N (%)c

882 (76.8)

532 (82.6)

242 (74.2)

 

Randomisation to late PN, N (%)

576 (50.2)

324 (50.3)

167 (51.2)

 

STRONGkids risk level, N (%)d

 Medium

1046 (91.1)

605 (93.9)

299 (91.7)

 

 High

102 (8.9)

39 (6.1)

27 (8.3)

 

PeLOD score first 24 he

22 (12–32)

31 (21–32)

21 (11–31)

 

PIM2 scoref

−2.7 (−3.6; –1.4)

−3.0 (−3.7; –1.7)

−2.7 (−3.8; –1.5)

 

PIM2 probability of death (%)g

6.3 (2.6–19.3)

5.0 (2.4–15.5)

6.5 (2.6–22.0)

 

Emergency admission, N (%)

554 (48.3)

218 (33.9)

159 (48.8)

 

Diagnostic category, N (%)

 Surgical

  Abdominal

51 (4.4)

19 (3.0)

7 (2.2)

 

  Burns

8 (0.7)

1 (0.2)

4 (1.2)

 

  Cardiac

517 (45.0)

377 (58.5)

128 (39.3)

 

  Neurosurgery-traumatic brain injury

106 (9.2)

51 (7.9)

40 (12.3)

 

  Thoracic

46 (4.0)

29 (4.5)

11 (3.4)

 

  Transplantation

22 (1.9)

6 (0.9)

7 (2.2)

 

  Orthopaedic surgery-trauma

50 (4.4)

32 (5.0)

18 (5.5)

 

  Other

31 (2.7)

13 (2.0)

13 (4.0)

 

 Medical

  Cardiac

44 (3.8)

13 (2.0)

15 (4.6)

 

  Gastrointestinal-hepatic

5 (0.4)

4 (0.6)

4 (1.2)

 

  Oncologic-hematologic

11 (1.0)

0 (0.0)

5 (1.5)

 

  Neurologic

77 (6.7)

33 (5.1)

19 (5.8)

 

  Renal

1 (0.1)

0 (0.0)

1 (0.3)

 

  Respiratory

116 (10.1)

38 (5.9)

26 (8.0)

 

  Other

63 (5.5)

28 (4.3)

28 (8.6)

 

Condition on admission

 Mechanical ventilation required, N (%)

1033 (90.0)

580 (90.1)

286 (87.7)

 

 ECMO or other assist device, required, N (%)

40 (3.5)

14 (2.2)

9 (2.8)

 

 Infection, N (%)

415 (36.1)

173 (26.9)

116 (35.6)

 
  1. Data are expressed as number (%) or median (IQR)
  2. STRONGkids Screening Tool for Risk on Nutritional Status and Growth, PeLOD Paediatric Logistic Organ Dysfunction, PIM2 Paediatric Index of Mortality 2, ECMO extracorporeal membrane oxygenation, PICU paediatric intensive care unit
  3. aThere were no significant differences in sex, age, and number of infants between matched subgroups of patients and controls
  4. bHeight and weight, expressed as percentiles of population norms, were calculated with the anthropometric calculators for normal children, based on the World Health Organisation Growth Charts for Canada (version 2015/02/24), and for children with syndromes known to affect height and weight (version 2014/09/25). Patients and healthy children were not matched for height and weight, as a growth delay is expected in critically ill children
  5. cDichotomizing label indicating whether or not the patient was suffering from any symptomatic chronic disease identified through screening of the patient’s medical history and hospital files
  6. dScores on the STRONGkids range from 0 to 5, with a score of 0 indicating a low risk of malnutrition, a score of 1–3 indicating medium risk, and a score of 4–5 indicating high risk
  7. ePeLOD scores range from 0 to 71, with higher scores indicating more severe illness
  8. fPIM2 scores, with higher scores indicating a higher risk of mortality
  9. gPIM2 probability of death, ranging from 0% to 100%, with higher percentages indicating a higher probability of death in PICU
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Critical Care

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