Table 5 Fractional target attainment (FTA) for empiric therapy for P. aeruginosa strains over the resistance breakpoint (MIC < 16 mg/L, 56,730 isolates)
RD [mL/d] | Dose (40% f T > MIC) | Dose (100% f T > MIC) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
0.5 g q12 | 0.5 g q8 | 1 g q12 | 1 g q8 | 2 g q8 | 2 g q8 PI | 0.5 g q12 | 0.5 g q8 | 1 g q12 | 1 g q8 | 2 g q8 | 2 g q8 PI | |
0 | 88.3 | 92.3 | 94.5 | 97.9 | 99.7 | 99.9 | 81.8 | 84.9 | 88.8 | 91.1 | 97.4 | 93.3 |
100 | 85.9 | 89.5 | 92.1 | 95.6 | 99.56 | 99.8 | 73.9 | 80.7 | 82.6 | 87.5 | 93.7 | 90.9 |
300 | 80.0 | 85.3 | 87.8 | 91.7 | 95.9 | 99.4 | 54.7 | 70.0 | 66.9 | 70.3 | 86.3 | 83.4 |