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Table 5 Fractional target attainment (FTA) for empiric therapy for P. aeruginosa strains over the resistance breakpoint (MIC < 16 mg/L, 56,730 isolates)

From: Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study

RD
[mL/d]
Dose (40% f T > MIC) Dose (100% f T > MIC)
0.5 g
q12
0.5 g
q8
1 g
q12
1 g
q8
2 g
q8
2 g q8 PI 0.5 g
q12
0.5 g
q8
1 g
q12
1 g
q8
2 g
q8
2 g q8 PI
0 88.3 92.3 94.5 97.9 99.7 99.9 81.8 84.9 88.8 91.1 97.4 93.3
100 85.9 89.5 92.1 95.6 99.56 99.8 73.9 80.7 82.6 87.5 93.7 90.9
300 80.0 85.3 87.8 91.7 95.9 99.4 54.7 70.0 66.9 70.3 86.3 83.4
  1. RD residual diuresis, f T > MIC percentage of time remaining concentration above MIC, PI prolonged infusion (3 h)