Variable | n | Usual care | n | Intervention | p value |
---|---|---|---|---|---|
Patients with reported complications during study period, n (%) | |||||
 GRV > 300 ml on study days 1–7 | 48 | 23 (48) | 51 | 28 (55) | 0.49 |
 Abdominal distention |  | 14 (29) |  | 16 (31) | 0.81 |
 Vomiting |  | 8 (17) |  | 13 (26) | 0.28 |
Calories from propofol over the study period, kcal, median [IQR] | 48 | 0 [0-110] | 51 | 0 [0-160] | 0.48 |
Blood test results on study day 7: | |||||
 ALP, U/L, mean (SD) | 38 | 165 (81) | 33 | 183 (103) | 0.40 |
 ALT, U/L, median [IQR] | 38 | 50 [23-86] | 34 | 58 [30-102] | 0.54 |
 GGT, U/L, mean (SD) | 38 | 196 (125) | 34 | 216 (126) | 0.51 |
 Bilirubin, mmol/L, median [IQR] | 38 | 15 [11-29] | 35 | 24 [14-53] | 0.47 |
 WCC, 0^9/L, mean (SD) | 38 | 18 (10) | 36 | 20 (10) | 0.18 |
 TG, mmol/L, median [IQR] | 37 | 2 [1-3] | 32 | 2 [2-4] | 0.18 |
 CRP, mg/L, median [IQR] | 37 | 110 [78-185] | 32 | 153 [105-216] | 0.06 |
Mean SOFA over study duration, mean (SE) | 48 | 8.0 (0.4) | 51 | 8.2 (0.4) | 0.75 |
Duration of mechanical ventilation, days, median [IQR] | 48 | 8 [5-18] | 51 | 10 [6-15] | 0.68 |
Duration of ICU stay, days, median [IQR] | 48 | 11 [6-17] | 51 | 11 [5-17] | 0.83 |
Duration of hospital stay, days, mean (SD) | 48 | 23 (17) | 51 | 22 (21) | 0.85 |
Survival | |||||
 ICU D/C, n (%) |  | 37 (77) |  | 36 (71) | 0.46 |
 Hospital D/C, n (%) | 48 | 37 (77) | 51 | 35 (67) | 0.37 |
 90 days, n (%) |  | 35 (73) |  | 32 (63) | 0.28 |
 180 days, n (%) |  | 35 (73) |  | 32 (63) | 0.28 |
EQ-5D-3L | |||||
 Hospital D/C, mean (SD) | 17 | 0.32 (0.36) | 27 | 0.25 (0.34) | 0.54 |
 90 days, median [IQR] | 29 | 0.76 (0.23) | 35 | 0.69 (0.24) | 0.29 |
 180 days, mean (SD) | 29 | 0.77 (0.24) | 35 | 0.75 (0.26) | 0.76 |
Hand grip strength at hospital D/C, kg, mean (SD) | 24 | 20 (8) | 19 | 19 (13.5) | 0.71 |
ICU mobility scale at hospital D/C, median [IQR] | 33 | 8 [4-10] | 25 | 9 [5-10] | 0.58 |
Mid arm muscle circumference, hospital D/C, cm, mean (SD) | 25 | 30 (5) | 22 | 30 (5) | 0.91 |