Skip to main content

Table 2 Blood glucose control in the two randomized groups

From: Software-guided versus nurse-directed blood glucose control in critically ill patients: the LOGIC-2 multicenter randomized controlled clinical trial

  Nurse-C LOGIC-C P value
   95% CI   95% CI  
Patients 773   777   
Study period, median (IQR), days 2 (2–4)   2 (2–4))   0.7
Efficacy
 Glycemic penalty index (GPI), median (IQR) 17.1 (10.6–26.2) 16.3–18.1 10.8 (6.2–16.1) 10.0–11.5 <0.001
 Blood glucose, mean (SD), mg/dL 119 (21) 118–121 111 (15) 110–112 <0.001
 Minimum blood glucose, mg/dL 21   26   
 Maximum blood glucose, mg/dL 428   511   
 Hyperglycemic index, median (IQR), mg/dL 8.3 (3.4–16.3) 7.5–8.8 3.5 (1.4–7.0) 3.1–4.0 <0.001
 Time-in-target range, median (IQR), percentage 47.1 (28.1–65.0) 45.7–49.3 67.0 (52.1–80.1) 65.4–68.6 <0.001
 Time to reach target range, median (IQR), h 3.6 (0–9.3) 3.2–4.3 2.2 (0–5.1) 1.8–2.5 <0.001
 Mean of maximum delta glycemia per day, median (IQR), mg/dL 36 (27–52) 35–38 34 (24–46) 32–36 <0.001
Safety
 Hypoglycemia, proportion of patients
  <70 mg/dL, n (%) 173 (22.4) 151–196 149 (19.2) 128 –171 0.1
  <60 mg/dL, n (%) 78 (10.1) 62–95 58 (7.5) 44–73 0.07
  <40 mg/dL, n (%) 9 (1.2) 4–15 7 (0.9) 2–13 0.6
 Hypoglycemia, proportion of samples
  <70 mg/dL, n (%) 346 (1.8) 311–382 342 (1.5) 306–379 0.02
  <60 mg/dL, n (%) 123 (0.7) 102–145 105 (0.5) 85–125 0.02
  <40 mg/dL, n (%) 9 (0.05) 4–15 9 (0.04) 4–15 0.9
Workload
 Sampling interval, mean (SD), h 3.0 (0.8) 2.9–3.0 2.3 (0.5) 2.3–2.3 <0.001
  1. Data are mean (SD), median (IQR) or n (%). LOGIC-C patients randomized to algorithm-guided blood glucose control, Nurse-C patients randomized to blood glucose control by trained nurses