Table 1 Ventilatory parameters at 24 h and mortality in clinical studies comparing a protective strategy (Vt limitation) versus a control group (top panel), and a strategy of high PEEP versus low PEEP or minimal distension (lower panel) in patients with ARDS
From: Driving pressure: a marker of severity, a safety limit, or a goal for mechanical ventilation?
Author | Year | N | Vt | Ppl | PEEP | DP | Mort | Vt | Ppl | PEEP | DP | Mort | Dif DP | p b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protective strategy | Control group | |||||||||||||
 Brochard | 1998 | 108 | 7.1 | 25.7 | 10.7 | 15 | 46.6% | 10.3 | 31.7 | 10.7 | 21 | 37.9% | 6 | NS |
 Stewart | 1998 | 120 | 7.2 | 22.3 | 8.6 | 13.7 | 48.0% | 10.8 | 26.8 | 7.2 | 19.6 | 46.0% | 5.9 | NS |
 Ranieria | 1999 | 44 | 7.6 | 24.6 | 14.8a | 9.8 | 38.0% | 11.1 | 31 | 6.5 | 24.5 | 58.0% | 14.7 | 0.19 |
 Brower | 1999 | 52 | 7.3 | 27 | 9.3 | 17.7 | 50.0% | 10.2 | 30 | 8.2 | 21.8 | 46.0% | 4.1 | NS |
 Amatoa | 1998 | 53 | 6 | 31.8 | 16.3a | 15.5 | 38.0% | 12 | 34.4 | 6.9 | 27.5 | 71.0% | 12 | <0.001 |
 ARDSnet | 2000 | 861 | 6.1 | 25 | 9.4 | 15.6 | 31.0% | 11.9 | 33 | 8.6 | 24.4 | 39.8% | 8.8 | 0.007 |
High PEEP | Low PEEP | |||||||||||||
 ALVEOLI | 2004 | 549 | 6.1 | 27 | 14.7 | 12.3 | 27.5% | 6.0 | 24 | 9.1 | 14.9 | 24.9% | 2.6 | NS |
 Mercat | 2008 | 767 | 6.1 | 27.5 | 15.8 | 11.7 | 35.4% | 6.1 | 21.1 | 8.4 | 12.7 | 39.0% | 1.0 | NS |
 Meade | 2008 | 983 | 6.8 | 30.2 | 15.6 | 14.6 | 36.4% | 6.8 | 24.9 | 10.1 | 14.8 | 40.4% | 0.2 | NS |
 Talmorc | 2008 | 61 | 7.1 | 28 | 17 | 11 | 17% | 6.8 | 25 | 10 | 15 | 39% | 4.0 | 0.055 |
 Kacmarek | 2016 | 200 | 5.6 | 27.9 | 15.8 | 11.8 | 22% | 6.2 | 25.2 | 11.6 | 13.8 | 27% | 2.0 | 0.18 |