Table 2 Baseline characteristics of the study population
Enhanced antibiotic de-escalation (n = 144) | Routine antibiotic management (n = 139) | P value | |
|---|---|---|---|
Age | 61 (52, 70) | 60 ([45, 71) | 0.494 |
Gender | |||
Male | 79 (54.9) | 80 (57.6) | 0.648 |
Female | 65 (45.1) | 59 (42.4) | |
Race | |||
Caucasian | 87 (60.4) | 82 (59.0) | 0.523 |
African American | 50 (34.7) | 54 (38.8) | |
Other | 7 (4.0) | 3 (2.1) | |
APACHE II score | 22.7 ± 7.3 | 21.7 ± 7.8 | 0.262 |
Charlson Comorbidity Index | 2.0 (1.0, 4.8) | 2.0 (1.0, 5.0) | 0.744 |
Clinical Pulmonary Infection Score | 7.2 ± 2.6 | 7.3 ± 2.4 | 0.730 |
Congestive heart failure | 22 (15.3) | 10 (14) | 0.701 |
Chronic obstructive lung disease | 42 (29.2) | 41 (29.5) | 0.951 |
Interstitial lung disease | 6 (4.2) | 5 (3.6) | 0.804 |
Cirrhosis | 8 (5.6) | 6 (4.3) | 0.631 |
Diabetes | 41 (28.5) | 48 (34.5) | 0.272 |
End-stage renal disease | 11 (7.6) | 7 (5.0) | 0.370 |
Malignancy | 35 (24.3) | 39 (28.1) | 0.473 |
HIV | 2 (1.4) | 4 (2.9) | 0.385 |
Solid organ transplant | 5 (3.5) | 4 (2.9) | 0.776 |
Home steroids | 20 (13.9) | 27 (19.4) | 0.211 |
Other home immunosuppressant | 16 (11.1) | 15 (10.8) | 0.931 |
Admission source | |||
Home | 58 (40.3) | 46 (33.1) | 0.213 |
Transfer from another hospital | 38 (26.3) | 38 (27.3) | |
Transfer from lower level of care | 30 (20.8) | 36 (25.9) | |
Nursing home/skilled nursing | 10 (6.9) | 12 (8.6) | |
Lateral ICU transfer | 2 (1.4) | 6 (4.3) | |
Long-term acute care hospital | 2 (1.4) | 1 (0.7) | |
Inpatient rehabilitation facility | 4 (2.8) | 0 (0.0) | |
Prior hospitalization | |||
Within 6 months | 74 (51.4) | 69 (49.6) | 0.769 |
Never or not within 6 months | 70 (48.6) | 70 (50.4) | |
Prior antibiotic exposure | |||
Within prior 30 days | 76 (52.8) | 64 (46.0) | 0.257 |
Not within prior 30 days | 68 (47.2) | 75 (54.0) | |