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Table 2 Microhemodynamics parameters before (baseline) and after hemorrhage followed by resuscitation treatment with normal saline, lactated Ringer’s solution, 5% albumin and fresh frozen plasma (post-resuscitation)

From: Low-volume resuscitation with normal saline is associated with microvascular endothelial dysfunction after hemorrhage in rats, compared to colloids and balanced crystalloids

 

Normal saline (n = 48)

Lactated Ringer’s solution (n = 34)

5% Albumin (n = 57)

Fresh frozen plasma (n = 38)

Parameters

Baseline

Post res

Baseline

Post res

Baseline

Post res

Baseline

Post Res

Venular diameter (μm)

16.6 (14.4–18.8]

16.0 (13.0–18.6)

16.6 (14.9–18.2)

16.0 (13.0–17.3)

15.5 (12.7–17.9)

14.4 (11.2–17.5)

15.4 (14.0–17.7)

14.6 (13.1–18.0)

RBC velocity (mm/s)

1.19 (0.85–2.04)

0.60 (0.30–1.19)a,b

1.42 (0.90–2.59)

0.78 (0.46–2.13)

1.37 (1.01–2.24)

0.92 (0.64–1.60)

1.28 (0.89–2.04)

0.82 (0.44–1.44)

Blood flow (×10-4 mm3/s)

1.43 (0.88–2.67)

0.73 (0.23–1.98)a

1.65 (1.02–3.21)

0.91 (0.49–2.31)a

1.51 (0.85–2.62)

0.86 (0.51–1.89)

1.59 (1.01–2.17)

0.82 (0.45–1.32)

Wall shear rate (× 103 s-1)

0.64 (0.35–1.96)

0.30 (0.17–0.51)a,b

0.69 (0.47–1.08)

0.49 (0.24–1.00)a

0.82 (0.42–1.20)

0.57 (0.38–0.85)

0.78 (0.42–1.11)

0.43 (0.19–0.86)

Wall shear stress (dyn/cm2)

3.20 (1.63–4.70)

0.83 (0.44–1.55)a,b,c

3.28 (2.46–4.50)

1.16 (0.56–2.33)a

3.17 (1.92–5.41)

1.88 (1.11–2.99)a

3.06 (2.04–4.08)

1.53 (0.77–4.06)a

  1. Values expressed as median (IQR) for all parameters. RBC red blood cell, Post res post resuscitation. aSignificantly different from baseline. bSignificantly different from the 5% albumin group. cSignificantly different from the fresh frozen plasma group