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Fig. 2 | Critical Care

Fig. 2

From: Low-volume resuscitation with normal saline is associated with microvascular endothelial dysfunction after hemorrhage in rats, compared to colloids and balanced crystalloids

Fig. 2

Change in microvascular permeability in rats resuscitated with normal saline (NS) (7 rats, 39 vessels), lactated Ringer’s solution (LR) (5 rats, 20 vessels), 5% albumin (6 rats, 32 vessels) or fresh frozen plasma (FFP) (7 rats, 28 vessels). Sham-procedure rats (time control) were not subjected to hemorrhage or resuscitation (6 rats, 25 vessels). The permeability index was calculated before and after injection of fluorescein isothiocyanate-bovine serum albumin (FITC-BSA), change in permeability was presented relative to the pre-FITC-BSA index. Permeability changes were higher after NS and LR treatments compared to albumin or FFP (p < 0.05). Box plots display median, interquartile range, minimum and maximum. aSignificantly different from the sham group. bSignificantly different from the 5% albumin group. cSignificantly different from the FFP group

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Critical Care

ISSN: 1364-8535