Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis

Table 3 Inflammatory markers and skeletal muscle adenosine triphosphate content in cohort 1

Parameters	Group	BL	BR	End	p Value
IL-6, pg/ml	Lac ≥10%	0 (0–0)	854 (481–990)	45 (37–204)	0.003^a
	Lac <10%	16 (0–180)	873 (531–1983)	166 (128–310)	<0.001^a
	Lac <10%	16 (0–180)	873 (531–1983)	166 (128–310)	0.047^b
CRP, pg/ml	Lac ≥10%	1.6 (0.6–2.9)	10.7 (5.6–12.8)	19.2 (9.9–39.8)	0.139^c
CRP, pg/ml	Lac <10%	3.2 (1.8–5.7)	16.7 (4.9–31.1)	16.7 (13.5–33.3)	0.139^c
TNF-α, pg/ml	Lac ≥10%	53 (38–55)	119 (94–169)	72 (47–88)	0.579^c
TNF-α, pg/ml	Lac <10%	47 (37–67)	178 (120–219)	92 (57–144)	0.579^c
ATP content, μmol/g wet tissue weight	Lac ≥10%	2.1 (1.2–2.3)	2.3 (1.8–3.1)	0.6 (0.4–0.9)	0.081^c
ATP content, μmol/g wet tissue weight	Lac <10%	2.8 (1.8–4.5)	3.3 (1.5–4.8)	0.6 (0.3–0.7)	0.081^c

Abbreviations: ATP Adenosine triphosphate, BL Baseline, BR Immediately before start resuscitation, End End of the experiment (at 48 h of resuscitation or before death if earlier), IL-6 Interleukin-6, CRP C-reactive protein, TNF-α Tumor necrosis factor-α
Values represent median (IQR)
^aTime effect with Friedman’s test including all time points
^bMann-Whitney U test at end of study
^cTime × group interaction with repeated-measures analysis of variance including all time points

ISSN: 1364-8535