Diagnostic value of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for acute kidney injury: a meta-analysis

Table 2 Diagnostic value of urinary [TIMP-2] × [IGFBP7] for acute kidney injury in individual studies

First author, year [reference]	Number of patients				Sensitivity (95% CI)	Specificity (95% CI)	AUC	Cutoff value
First author, year [reference]	TP	FP	FN	TP	Sensitivity (95% CI)	Specificity (95% CI)	AUC	Cutoff value
Kashani, 2013 [8]	90	313	11	314	0.89 (0.81–0.94)	0.50 (0.46–0.54)	0.80	0.3
Bihorac, 2014 [21]	65	182	6	155	0.92 (0.83–0.97)	0.46 (0.41–0.51)	0.82	0.3
Hoste, 2014 [22]	24	59	3	67	0.89 (0.71–0.98)	0.53 (0.44–0.62)	0.79	0.3
Meersch, 2014 [23]	21	4	5	20	0.81 (0.61–0.93)	0.83 (0.63–0.95)	0.81	0.3
Wetz, 2015 [24]	8	1	8	25	0.50 (0.25–0.75)	0.96 (0.80–1.00)	0.71	1.07
Pilarczyk, 2015 [25]	5	10	1	44	0.89 (0.36–1.00)	0.81 (0.69–0.91)	0.82	0.89
Gocze, 2015 [26]	32	9	13	53	0.71 (0.56–0.84)	0.85 (0.74–0.93)	0.85	0.3
Kimmel, 2016 [27]	35	118	11	134	0.76 (0.61–0.87)	0.53 (0.47–0.59)	0.76	0.3
Dusse, 2016 [28]	8	3	0	29	1.00 (0.63–1.00)	0.91 (0.75–0.98)	0.97	1.03

Abbreviations: IGFBP7 Insulin-like growth factor-binding protein 7, TIMP-2 Tissue inhibitor of metalloproteinase-2; TP True-positive, FP False-positive, FN False-negative, TP True-negative

ISSN: 1364-8535