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Table 2 Association of admission glucocorticoid levels with short- and long-term all-cause mortality in community-acquired pneumonia

From: Time-dependent association of glucocorticoids with adverse outcome in community-acquired pneumonia: a 6-year prospective cohort study

Entire cohort (N = 285) All-cause mortality time point  
30 days 3 years 6 years  
  HR (95% CI) p Value HR (95% CI) p Value HR (95% CI) p Value
Cortisol
 Cox regression analyses
  Univariate model 2.47 (95% CI 0.50–12.18) 0.268 0.54 (95% CI 0.32–0.9) 0.018 0.63 (95% CI 0.41–0.99) 0.045
  Multivariate modela 1.93 (95% CI 0.51–9.02) 0.405 0.53 (95% CI 0.32–0.89) 0.017 0.57 (95% CI 0.36–0.90) 0.015
11-Deoxycortisol
 Cox regression analyses
  Univariate model 1.37 (95% CI 0.75–2.53) 0.309 0.95 (95% CI 0.76–1.18) 0.631 1.04 (95% CI 0.86–1.24) 0.710
  Multivariate modela 1.26 (95% CI 0.65–2.44) 0.486 0.84 (95% CI 0.67–1.05) 0.126 0.91 (95% CI 0.75–1.1) 0.336
Cortisone
 Cox regression analyses
  Univariate model 1.37 (95% CI 0.31–6.02) 0.677 0.56 (95% CI 0.33–0.94) 0.028 0.6 (95% CI 0.38–0.95) 0.030
  Multivariate modela 2.55 (95% CI 0.38–17.30) 0.337 0.71 (95% CI 0.4–1.25) 0.237 0.76 (95% CI 0.46–1.24) 0.272
Corticosterone
 Cox regression analyses
  Univariate model 1.33 (95% CI 0.63–2.81) 0.457 0.77 (95% CI 0.57–1.03) 0.082 0.85 (95% CI 0.66–1.09) 0.199
  Multivariate modela 1.21 (95% CI 0.55–2.65) 0.637 0.76 (95% CI 0.57–1.02) 0.067 0.81 (95% CI 0.63–1.03) 0.084
  1. Data for univariate and multivariate Cox regression models are presented as HR (95% CI), p value; p < 0.05 is considered statistically significant. Bold values indicate statistical significance. All hormone levels were log-transformed, and thus the HR corresponds to a tenfold increase in these levels
  2. aMultivariate model is adjusted for age, sex, and comorbidities (coronary artery disease, cerebrovascular disease, chronic kidney disease, neoplastic disease)