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Table 2 Blood cell count

From: Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis

  

0 h

1 h

2 h

4 h

6 h

8 h

12 h

16 h

20 h

24 h

P value

Erythrocytes Mio/μL

CO

5.8 ± 0.4

5.8 ± 0.4

5.7 ± 0.5

5.9 ± 0.5

6.1 ± 0.6

6.2 ± 0.6

6.1 ± 0.7

5.7 ± 0.7

5.1 ± 0.8

4.5 ± 0.8

0.716*

LD SATI

5.8 ± 0.5

5.7 ± 0.4

5.7 ± 0.5

5.6 ± 0.6

5.7 ± 0.5

5.8 ± 0.6

5.9 ± 0.6

5.3 ± 0.6

4.9 ± 0.8

4.7 ± 0.5

0.511#

HD SATI

5.8 ± 0.4

5.8 ± 0.5

5.7 ± 0.6

5.8 ± 0.7

6.0 ± 0.8

6.0 ± 0.8

5.9 ± 0.8

5.8 ± 0.8

5.5 ± 0.8

5.1 ± 0.8

0.194§

Hct %

CO

44.7 ± 2.3

44.7 ± 2.1

44.7 ± 2.3

45.2 ± 3.1

46.6 ± 3.7

47.5 ± 3.8

46.7 ± 4.6

43.4 ± 5.2

39.8 ± 6.1

35.6 ± 6.3

0.327*

LD SATI

43.9 ± 2.9

43.0 ± 2.0

43.0 ± 4.0

42.4 ± 2.9

42.9 ± 2.9

43.4 ± 3.3

42.2 ± 3.0

40.0 ± 3.5

36.8 ± 4.7

35.7 ± 3.4

0.980#

HD SATI

43.9 ± 2.9

43.7 ± 3.3

45.2 ± 3.1

43.8 ± 5.3

45.0 ± 5.9

45.4 ± 6.2

44.4 ± 6.1

43.6 ± 5.9

41.2 ± 6.2

38.8 ± 1.3

0.299§

Hb g/dL

CO

14.6 ± 0.9

14.8 ± 1.1

14.6 ± 1.3

14.9 ± 0.9

15.5 ± 1.4

15.7 ± 1.5

15.6 ± 1.8

14.5 ± 2.0

13.3 ± 2.1

11.8 ± 2.1

0.460*

LD SATI

14.7 ± 1.0

14.5 ± 0.7

14.4 ± 0.9

14.3 ± 1.1

14.4 ± 0.9

14.6 ± 1.0

14.3 ± 1.1

13.3 ± 1.2

12.2 ± 1.8

12.0 ± 1.2

0.918#

HD SATI

14.2 ± 1.2

14.3 ± 1.2

14.0 ± 1.4

14.3 ± 1.8

14.6 ± 2.1

14.6 ± 2.3

14.3 ± 2.2

14.1 ± 2.0

13.2 ± 2.0

12.2 ± 2.0

0.321§

WBC G/L

CO

8,994 ± 2.951

4,684 ± 2.089

1,323 ± 0.375

1,463 ± 791

1,750 ± 1603

2,454 ± 3,026

1,090 ± 493

5,689 ± 7,504

7,244 ± 9,355

6,935 ± 9,047

0.988*

LD SATI

7,413 ± 3.200

5,141 ± 1.831

2,099 ± 1.773

1,645 ± 681

1,619 ± 1.066

1,864 ± 1,757

3,424 ± 3,471

4,271 ± 4,009

5,391 ± 3,863

7,523 ± 4,379

0.547#

HD SATI

8,250 ± 3.47

3,417 ± 0.80

1,250 ± 0,476

1,233 ± 423

867 ± 186

833 ± 151

1,383 ± 256

1,833 ± 459

2,350 ± 764

3,267 ± 1,515

0.493§

  1. Values are presented as mean and SD. Hct hematocrit, Hb hemoglobin, WBC white blood cell count, CO control; HD-SATI; high-dose activated factor II and activated factor X inhibitor-group; LD-SATI; high-dose activated factor II and activated factor X inhibitor-group. P values are given for between-subjects analysis: *control vs LD-SATI; #control vs HD-SATI; §LD-SATI vs HD-SATI