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Fig. 3 | Critical Care

Fig. 3

From: Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis

Fig. 3

a-f Natural coagulation inhibitors, natural fibrinolysis inhibitors and D-Dimers starting from baseline (time point 0 h) until the end of the experiment (time point 24 h). Arrow represents the duration of E. coli infusion (first 2 h). White control group (CO), light gray low-dose short-acting thrombosis inhibitor (LD-SATI), dark gray high-dose (HD)-SATI. a Antithrombin III (AT III) ; b activated protein C (APC); c tissue factor pathway inhibitor (TFPI); d plasminogen activator inhibitor 1 (PAI-1); e thrombin-activated fibrinolysis inhibitor antigen (TAFI); f D-Dimer. CO vs HD-SATI ***p < 0.001, **p < 0.01, *p < 0.05; CO vs HD-SATI ### p < 0.001, ## p < 0.01, # p < 0.05; no indication = not significant. Two-factor analysis of variance was used for between-group comparisons. Gray arrow represents the time of E. coli infusion

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Critical Care

ISSN: 1364-8535