Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock

Table 4 Association between acute kidney injury and the polymorphisms studied in 478 patients in septic shock (additive genetic model)

Single nucleotide polymorphism	Univariate odds ratio (95% confidence interval)	Univariate P value	Multivariate odds ratio (95% confidence interval)^a	Multivariate P value
rs625145	0.81 (0.59–1.11)	0.19	0.80 (0.56–1.13)	0.20
rs1955656	0.71 (0.46–1.07)	0.10	0.63 (0.40–0.98)	0.043
rs2093266	0.71 (0.46–1.07)	0.10	0.63 (0.40–0.98)	0.043
rs8094315	1.19 (0.88–1.62)	0.27	1.13 (0.81–1.58)	0.48
rs12457893	1.24 (0.94–1.62)	0.13	1.22 (0.91–1.64)	0.19

^aAdjusted for body mass index, use of non-steroidal anti-inflammatory drugs as daily medication, arteriosclerosis, chronic obstructive pulmonary disease, administration of contrast medium prior to ICU admission, administration of colloids prior to ICU admission, simplified acute physiology score II without age or renal components, operative admission, and source of infection

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