Table 3 Primary and secondary clinical outcomes in the ScvO2-oriented group and lactate kinetics-oriented group
Lactate kinetics group | Central venous oxygen saturation (ScvO2) group | P value | |
|---|---|---|---|
n = 180 | n = 180 | ||
Mortality at 60 days | 33 (18.3%) | 50 (27.9%) | 0.033 |
Mechanical ventilation time, h | 25 (14–97) | 35 (16–106) | 0.465 |
ICU stay time, h | 68 (24–138) | 66 (27–166) | 0.348 |
Organ dysfunction | |||
Alanine aminotransferase, g/L | |||
0 h | 106.0 (53.5–156.5) | 78.0 (46.0–142.0) | 0.161 |
24 h | 125.0 (74.0–177.0) | 118 (62.8–186.8) | 0.844 |
48 h | 114 (73.0–157) | 109 (67–150) | 0.47 |
72 h | 113 (72–160.8) | 109 (74–161.5) | 0.725 |
Total bilirubin, mmol/L | |||
0 h | 19.5 (11.6–37.2) | 18.1 (10.7–41.9) | 0.807 |
24 h | 17.7 (11.7–32.4) | 17.8 (10.7–38.7) | 0.843 |
48 h | 21.4 (13.3–35.5) | 21.0 (12.6–50.8) | 0.564 |
72 h | 20.3 (13.1–33.7) | 19.0 (11.8–40.2) | 0.865 |
Serum creatinine, μmol/L | |||
0 h | 91.5(65.3–163.5) | 102(65.5–182.5) | 0.484 |
24 h | 79(59.0–128) | 80(62.0–130) | 0.443 |
48 h | 81(58–117) | 83(63.2–139.8) | 0.217 |
72 h | 72.5(53.8–111.5) | 76(58–141) | 0.123 |
Cardiac troponin I, μg/L | |||
0 h | 0.42 (0.04–3.40) | 0.29 (0.05–2.97) | 0.635 |
24 h | 0.14 (0.016–2.12) | 0.12 (0.02–1.52) | 0.766 |
48 h | 0.30 (0.02–2.46) | 0.21 (0.04–2.79) | 0.745 |
72 h | 0.19 (0.01–1.74) | 0.15 (0.03–1.67) | 0.61 |
Hemodynamic parameters | |||
Heart rate, beats per minute | |||
0 h | 109 ± 25 | 114 ± 28 | 0.184 |
24 h | 107 ± 24 | 112 ± 23 | 0.183 |
48 h | 99 ± 20 | 105 ± 19 | 0.04 |
72 h | 96 ± 24 | 99 ± 17 | 0.467 |
Mean arterial pressure, mmHg | |||
0 h | 83(72–93) | 87(76–100) | 0.113 |
24 h | 86 (74–96) | 88 (75–99) | 0.712 |
48 h | 88 ± 15 | 85 ± 18 | 0.37 |
72 h | 91 ± 12 | 87 ± 15 | 0.111 |
Central venous pressure, mmHg | |||
0 h | 7 (5–8) | 7 (6–8) | 0.866 |
2 h | 8 (6–10) | 8 (7–10) | 0.573 |
4 h | 8 (6–10) | 7 (5–9) | 0.039 |
6 h | 9 (6–13) | 8 (5–11) | 0.027 |
12 h | 9 (7–11) | 8 (6–10) | 0.041 |
24 h | 9 (7–11) | 8.5 (7–11) | 0.695 |
48 h | 9 (7.3–10) | 9 (7–10) | 0.901 |
72 h | 8 (6.3–10) | 8 (6–9.7) | 0.064 |