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Table 2 Interventions in the ScvO2-oriented group and lactate kinetics-oriented group during the treatment process

From: Use of stepwise lactate kinetics-oriented hemodynamic therapy could improve the clinical outcomes of patients with sepsis-associated hyperlactatemia

 

Lactate kinetics group

ScvO2 group

P value

n = 180

n = 180

RBC volume at 24 h, ml

144 ± 192

152 ± 193

0.705

Norepinephrine, %

 1st day

46.1% (83/180)

46.7% (84/180)

0.916

 2nd day

38.9% (70/180)

40.6% (73/180)

0.747

 3rd day

27.2% (49/180)

30.3% (54/180)

0.560

Norepinephrine, μg/kg/h

 

0 (0–4.46)

0 (0–7.75)

0.843

0 (0–3.67)

0 (0–7.19)

0.1

0 (0–0.57)

0 (0–2.45)

0.272

Dobutamine, %

 1st day

2.2% (4/180)

3.9% (7/180)

0.358

 2nd day

4.4% (8/180)

3.3% (6/180)

0.586

 3rd day

3.9% (7/180)

3.3% (6/180)

0.778

Dobutamine, μg/kg/h

 1st day

0 (0–0)

0 (0–0)

0.325

 2nd day

0 (0–0)

0 (0–0)

0.263

 3rd day

0 (0–0)

0 (0–0)

0.618

 CVVH

26/154

36/144

0.163

Fluid volume, ml

 0–2 h

563 (259–922)

590 (288–960)

0.539

 2–4 h

1535 (1271–1778)

826 (631–1219)

<0.001

 4–6 h

1687 (1476–1929)

1255 (1008–1537)

0.358

 6–12 h

1688 (1173–1923)

1277 (962–1588)

<0.001

 12–24 h

1510 (904–2087)

1236 (740–1808)

0.005

 24–48 h

465 (341–606)

424 (279–552)

0.071

 48–72 h

278 (159–410)

284 (226–324)

0.502

  1. ScvO 2 central venous oxygen saturation, CVVH continuous veno-venous hemofiltration