Table 1 Characteristics of included trials
Characteristic | Number of trials (% of 87 included) or median (IQR) |
|---|---|
Trial population, n (%) | |
Severe sepsis or septic shock | 35 (40%) |
Mixed ICU population | 24 (28%) |
Specific organ dysfunction | 13 (15%) |
Trauma | 4 (5%) |
Cardiac surgery | 2 (2%) |
Other | 9 (10%) |
Trial intervention, n (%) | |
Drug | 47 (54%) |
Treatment bundle | 12 (14%) |
Device | 10 (11%) |
Nutrition | 8 (9%) |
Ventilation-related | 4 (5%) |
Other | 6 (7%) |
Jadad scale, median (IQR) | 3 (2 – 3) |
Jadad scale ≤1, n (%) | 14 (16%) |
Multicenter design, n (%) | 40 (46%) |
Sample size per trial, median (IQR) | 64 (40 – 147) |
Mean or median baseline SOFA score, median (IQR) | 8.5 (7 – 10) |
Mortality rate, median (IQR) | 28% (19% – 36%) |
Primary endpoint, n (%) | |
SOFA score | 19 (22%) |
Mortality | 14 (16%) |
Other | 36 (41%) |
Not specified | 18 (21%) |