Table 2 Pharmacokinetics of caspofungin during continuous venovenous hemodiafiltration in 12 patients
AUC0-24 (mg h/L) | ||||||||
|---|---|---|---|---|---|---|---|---|
Patient | Arterial | Venous | Difference venous to arterial (%) | Vd (L) | Cl (L/h) | Cmax (mg/L) | Ctrough (mg/L) | t½ (h) |
1 | 140.0 | 180.0 | 29 | 14.1 | 0.356 | 12.5 | 3.47 | 27.4 |
2 | 88.3 | 106.0 | 20 | 17.1 | 0.567 | 7.8 | 2.1 | 21.0 |
3 | 124.0 | 152.0 | 23 | 10.9 | 0.402 | 8.8 | 3.1 | 18.8 |
4 | 65.4 | 77.4 | 18 | 26.8 | 0.765 | 6.9 | 1.3 | 24.3 |
5 | 68.0 | 90.0 | 32 | 17.5 | 0.735 | 4.8 | 1.5 | 16.5 |
6 | 102.0 | 107.0 | 5 | 13.6 | 0.683 | 10.7 | 2.5 | 13.8 |
7 | 65.6 | 78.8 | 20 | 15.0 | 0.762 | 8.3 | 1.6 | 13.6 |
8 | 100.0 | 113.0 | 13 | 13.9 | 0.499 | 9.5 | 2.7 | 19.3 |
9 | 102.0 | 127.0 | 25 | 14.1 | 0.685 | 9.2 | 2.3 | 14.3 |
10 | 121.0 | 142.0 | 17 | 12.5 | 0.578 | 12.6 | 2.9 | 15.0 |
11 | 190.0 | 224.0 | 18 | 13.9 | 0.368 | 11.5 | 4.0 | 26.2 |
12 | 60.1 | 74.5 | 24 | 27.7 | 1.165 | 8.5 | 1.9 | 16.5 |
Mean ± SD | 102 ± 46 | 123 ± 46 | 20.3 ± 7.2 | 16.4 ± 5.4 | 0.630 ± 0.225 | 9.3 ± 2.3 | 2.4 ± 0.8 | 18.9 ± 4.9 |