Table 1 Hemodynamic parameters
Baseline (T0) | T1 | T2 | T3 | |
|---|---|---|---|---|
Mean arterial pressure (mmHg) | ||||
Control | 91.5 ± 4.2 | 93 ± 4.1 | 94 ± 4.8 | 76.1 ± 2.3 |
LPS | 88.7 ± 1.3 | 49 ± 5.1## | 54.9 ± 6.2## | 42.2 ± 4.4### |
LPS + FR | 90.8 ± 1.3 | 53.5 ± 3.2## | 82.7 ± 2.1* | 56.6 ± 2.1*,## |
LPS + BT | 89.5 ± 2.2 | 54.1 ± 1.7## | 86.8 ± 1.7* | 61.1 ± 3.2* |
Heart rate (beats per minute) | ||||
Control | 232.9 ± 8.5 | 247.7 ± 7.7 | 248 ± 6.4 | 249.9 ± 13.4 |
LPS | 236.3 ± 11.9 | 225.6 ± 5.2 | 226.9 ± 5.9 | 221 ± 8.5 |
LPS + FR | 227.9 ± 8.7 | 219 ± 5.1 | 259 ± 7.7 | 258 ± 4.3 |
LPS + BT | 255.3 ± 7.7 | 252.1 ± 5.6 | 258 ± 5.3 | 254.6 ± 6.5 |
Renal blood flow (ml/min) | ||||
Control | 7.5 ± 0.8 | 5.1 ± 0.2 | 5.2 ± 0.3 | 4.3 ± 0.2 |
LPS | 7.1 ± 0.5 | 0.8 ± 0.3# | 0.9 ± 0.3### | 0.6 ± 0.3### |
LPS + FR | 6.3 ± 0.2 | 0.4 ± 0.1## | 5.4 ± 0.9** | 1.6 ± 0.3# |
LPS + BT | 6.6 ± 0.7 | 0.8 ± 0.3# | 3.2 ± 0.4* | 1.8 ± 0.3# |
Renal vascular resistances (dynes·s·cm–5) | ||||
Control | 1291.9 ± 128.2 | 1823.2 ± 88.2 | 1844.4 ± 155.9 | 1784.3 ± 96.4 |
LPS | 1275.2 ± 77.6 | 17,820 ± 7905.5 | 18,631.9 ± 11,394.9 | 20,237.7 ± 7939.2 |
LPS + FR | 1449.9 ± 61.8 | 18,860.5 ± 6758.4 | 1853.3 ± 336.2 | 4390.5 ± 920.3 |
LPS + BT | 1431.3 ± 124.1 | 12,133.9 ± 3493.6 | 2919.9 ± 388.8 | 4860.7 ± 1828.1 |