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Table 2 Patient characteristics, vasoactive use and fluid balance in ICU patients with oliguric AKI

From: Early-phase cumulative hypotension duration and severe-stage progression in oliguric acute kidney injury with and without sepsis: an observational study

 

Stage-3 progression

No progression

P value

(n = 54)

(n = 484)

 

Characteristics

Age (years; median (IQR))

69 (61–78)

70 (59–77)

0.647

Male (%)

41 (75.9)

335 (69.2)

0.351

Body weight (kg; median (IQR))

62.0 (52.3–67.8)

60.0 (50.0–70.0)

0.571

Comorbidities (%)

 Immunocompromised

8 (14.8)

42 (8.7)

0.141

 Hematologic malignancy

2 (3.7)

12 (2.5)

0.642

 Metastasis

0 (0.0)

14 (2.9)

0.380

 Respiratory failure

3 (5.6)

19 (3.9)

0.476

 Heart failure

0 (0.0)

2 (0.4)

1.000

 Liver failure

3 (5.6)

8 (1.7)

0.088

Ward type before ICU admission (%)

 Operating room

18 (33.3)

260 (53.7)

0.008

  Cardiac surgery

10 (18.5)

127 (26.2)

 

  Thoracic surgery

2 (3.7)

42 (8.7)

  Neurosurgery

0 (0.0)

31 (6.4)

  Other major surgery

6 (11.1)

60 (12.4)

 General ward

21 (38.9)

109 (22.5)

 Emergency department

15 (27.8)

115 (23.8)

Sepsis at ICU admission (%)

27 (50.0)

111 (22.9)

<0.001

Serum creatinine at ICU admission (mg/dL; median (IQR))

1.54 (1.04–3.10)

0.86 (0.67–1.19)

<0.001

Time to oliguric AKI (hours; median (IQR))

10.7 (7.4–28.5)

19.0 (10.7–35.5)

0.001

APACHE II score (median (IQR))

22 (17–27)

17 (13–21)

<0.001

SOFA score (median (IQR))

11 (8–13)

7 (4–9)

<0.001

 Respiratory

2 (1–3)

2 (1, 2)

0.182

 Coagulation

2 (0–2)

1 (0–2)

0.009

 Liver

1 (0–1)

0 (0–1)

0.098

 Cardiovascular

4 (1–4)

3 (1–4)

0.040

 Central nervous system

0 (0–1)

0 (0–1)

0.130

 Renal

3 (1–3)

0 (0–1)

<0.001

Vasoactive use within 6 h after oliguric AKI diagnosis

 Dopamine (%)

0 (0.0)

10 (2.1)

0.609

 Dobutamine (%)

9 (16.7)

97 (20.0)

0.718

 Norepinephrine (%)

36 (66.7)

205 (42.4)

0.001

 Vasopressin (%)

6 (11.1)

14 (2.9)

0.010

Fluid balance during the first measurable 8-h period after oliguria starting

 In (mL; median (IQR))

949 (691–1526)

758 (530–1096)

0.004

 Out (mL; median (IQR))

272 (158–413)

326 (200–506)

0.028

 Balance (mL; median (IQR))

723 (386–1278)

432 (179–759)

<0.001

  1. Time to oliguric acute kidney injury (AKI), time between ICU admission and oliguric AKI diagnosis. Sequential Organ Failure Assessment (SOFA) scores were calculated using information during the first 24-h period after ICU admission. APACHE Acute Physiology and Chronic Health Evaluation, IQR interquartile range