Table 2 Estradiol and carrier protein concentrations
| Â | Control subjects vs. sepsis patients | Â | Sepsis, survivors vs. nonsurvivors | Â | ||
|---|---|---|---|---|---|---|
Variable | Controls (n = 51) | Sepsis (n = 131) | p Value | Survivors (n = 98) | Nonsurvivors (n = 33) | p Value |
Total estradiol, pM | 115 (88–166) | 275 (112–916) | <0.01 | 222 (100–814) | 512 (276–1040) | 0.01 |
Albumin-bound estradiol, pM | 97 (76–139) | 199 (74–637) | <0.01 | 156 (66–538) | 278 (154–855) | 0.04 |
Free estradiol, pM | 3 (2–4) | 10 (4–46) | <0.01 | 8 (4–28) | 23 (10–73) | <0.01 |
Bioavailable estradiol, pM | 100 (78–142) | 211 (78–675) | <0.01 | 167 (70–566) | 312 (164–918) | 0.04 |
Albumin, g/dl | 5.24 (4.61–5.71) | 2.67 (2.06–3.49) | <0.01 | 3.00 (2.30–3.74) | 2.06 (1.72–2.63) | <0.01 |
SHBG, nM | 9.52 (4.13–22.06) | 19.00 (10.50–32.80) | <0.01 | 19.00 (11.20–32.50) | 17.41 (7.92–34.19) | 0.70 |