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Table 2 Estradiol and carrier protein concentrations

From: Bioavailable estradiol concentrations are elevated and predict mortality in septic patients: a prospective cohort study

  Control subjects vs. sepsis patients   Sepsis, survivors vs. nonsurvivors  
Variable Controls (n = 51) Sepsis (n = 131) p Value Survivors (n = 98) Nonsurvivors (n = 33) p Value
Total estradiol, pM 115 (88–166) 275 (112–916) <0.01 222 (100–814) 512 (276–1040) 0.01
Albumin-bound estradiol, pM 97 (76–139) 199 (74–637) <0.01 156 (66–538) 278 (154–855) 0.04
Free estradiol, pM 3 (2–4) 10 (4–46) <0.01 8 (4–28) 23 (10–73) <0.01
Bioavailable estradiol, pM 100 (78–142) 211 (78–675) <0.01 167 (70–566) 312 (164–918) 0.04
Albumin, g/dl 5.24 (4.61–5.71) 2.67 (2.06–3.49) <0.01 3.00 (2.30–3.74) 2.06 (1.72–2.63) <0.01
SHBG, nM 9.52 (4.13–22.06) 19.00 (10.50–32.80) <0.01 19.00 (11.20–32.50) 17.41 (7.92–34.19) 0.70
  1. SHBG Sex hormone-binding globulin
  2. Values are given as median (interquartile range)