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Fig. 1 | Critical Care

Fig. 1

From: Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study

Fig. 1

Diagnostic plots for the final population pharmacokinetics model. Individual predicted meropenem concentrations in serum versus observed serum concentrations (r 2 = 0.926) (a) and individual predicted meropenem concentrations in cerebrospinal fluid (CSF) versus observed CSF concentrations (r 2 = 0.694) (b), indicating that 92.6 % in serum and 69.4 % in CSF of the observed variability in meropenem concentrations were explained by the parametric distributions in the model. The solid black line shows the linear regression line of fit. The estimates of bias and imprecisions were also acceptable (−0.172 and 1.47 in serum and −0.0545 and 0.389 in CSF, respectively)

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Critical Care

ISSN: 1364-8535