Patients | All patients (n = 174) | Bacterial group (n = 46) | Viral group (n = 53) | Mixed group (n = 45) | No etiology group (n = 30) | p valuea |
---|---|---|---|---|---|---|
Age, y | 63 [53;75] | 64 [53;75] | 64 [54;75] | 63 [54;75] | 66 [57;78] | 0.85 |
Sex, male | 132 (75.9) | 37 (80.4) | 38 (71.7) | 33 (73.3) | 24 (80) | 0.69 |
Weight, kg | 71 [62;82] | 70 [60;80] | 71 [64;84] | 70 [60;77] | 75 [62;83] | 0.64 |
Smoking | 53 (31.7) | 16 (37.2) | 16 (30.8) | 13 (30.2) | 8 (27.6) | 0.83 |
McCabe score > 1 | 38 (21.8) | 7 (15.2) | 13 (24.5) | 12 (26.7) | 6 (20) | 0.56 |
WHO performance status > 0 | 53 (33.5) | 10 (22.7) | 19 (41.3) | 14 (35.9) | 10 (34.5) | 0.30 |
Chronic immunosuppression | 57 (32.8) | 16 (34.8) | 21 (39.6) | 14 (31.1) | 6 (20) | 0.32 |
HIV | 14 (8) | 7 (15.2) | 3 (5.7) | 3 (6.7) | 1 (3.3) | 0.20 |
Steroid therapy | 19 (10.9) | 2 (4.3) | 10 (18.9) | 6 (13.3) | 1 (3.3) | 0.06 |
Other immunosuppressive | 21 (12.4) | 3 (6.5) | 10 (20) | 7 (15.6) | 1 (3.4) | 0.08 |
Solid organ transplantation | 14 (8) | 2 (4.3) | 5 (9.4) | 6 (13.3) | 1 (3.3) | 0.31 |
Cancer | 15 (8.6) | 6 (13) | 4 (7.5) | 2 (4.4) | 3 (10) | 0.51 |
Chronic diseaseb | 86 (49.4) | 20 (43.5) | 34 (64.2) | 20 (44.4) | 12 (40) | 0.08 |
Coronary artery disease | 27 (15.5) | 6 (13) | 9 (17) | 9 (20) | 3 (10) | 0.64 |
HCAPc | 86 (49.4) | 22 (47.8) | 31 (58.5) | 22 (48.9) | 11 (36.7) | 0.29 |
Transfer from another wardd | 58 (33.3) | 14 (30.4) | 19 (35.8) | 17 (37.8) | 8 (26.7) | 0.72 |
Antibiotics before ICU admissione | 77 (44.3) | 15 (32.6) | 30 (56.6) | 19 (42.2) | 13 (43.3) | 0.12 |
Organ failures on ICU admission | ||||||
Glasgow < 15 | 42 (24.1) | 14 (30.4) | 11 (20.8) | 11 (24.4) | 6 (20) | 0.66 |
Shock | 32 (18.4) | 14 (30.4) | 3 (5.7) | 11 (24.4) | 4 (13.3) | <0.01 |
PaO2/FIO2 ratio | 174 [130;230] | 173 [130;229] | 172 [122;227] | 165 [134;228] | 200 [165;252] | 0.22 |
SAPS II score | 38 [27;55] | 39 [32;60] | 36 [26;48] | 46 [34;59] | 33 [18;46] | 0.02 |
PSI score at hospital referral | 106 [78;130] | 110 [84;152] | 98 [82;128] | 119 [98;126] | 89 [70;121] | 0.12 |
PSI class IV-V at hospital referral | 114 (65.5) | 31 (67.4) | 33 (62.3) | 36 (80) | 14 (46.7) | 0.03 |
Organ supports during ICU stay | ||||||
Noninvasive ventilation | 55 (31.8) | 14 (30.4) | 21 (40.4) | 12 (26.7) | 8 (26.7) | 0.44 |
Mechanical ventilation | 98 (56.3) | 28 (60.9) | 22 (41.5) | 36 (80) | 12 (40) | <0.01 |
ARDS | 60 (34.5) | 17 (37) | 13 (24.5) | 22 (48.9) | 8 (26.7) | 0.06 |
Dialysis | 37 (21.3) | 10 (21.7) | 10 (18.9) | 12 (26.7) | 5 (16.7) | 0.72 |
Vasopressors | 80 (46.2) | 22 (47.8) | 19 (36.5) | 27 (60) | 12 (40) | 0.12 |
Outcome | ||||||
Length of mechanical ventilation, d | 9 [5;13] | 6.5 [3;12.5] | 7 [4;12] | 9 [6;14] | 10 [7.5;17.5] | 0.34 |
Follow-up duration, df | 15 [10 ; 29] | 14 [5;23] | 18 [12;32] | 16 [11;31] | 14.5 [12;19] | 0.25 |
Hospital mortality | 30 (17.2) | 6 (13) | 6 (11.3) | 13 (28.9) | 5 (16.7) | 0.10 |
Complicated courseg | 74 (42.5) | 18 (39.1) | 15 (28.3) | 31 (68.9) | 10 (33.3) | <0.01 |