Table 2 Mixed models analysis of HLA-DR expression and LPS-induced TNF-ɑ production in 28-day survivors and non-survivors

HLA-DR expression (antibodies/cell), median (IQR)

Sample A (days 1–2)^a

7495 (4672, 15,824)

n = 51

6971 (2525, 9162)

n = 22

Sample B (days 3–4)^a

11351 (4316, 18,417)

n = 43

5895 (2900, 10,388)

n = 16

Sample C (days 6–8)^a

14470 (7656, 17,906)

n = 18

6195 (3721, 9662)

n = 10

Δ Sample A to B

434 (-1710, 2921)

-630 (-1795, 626)

Δ Sample A to C

1662 (-2645, 8118)

810 (-3382, 3507)

LPS-induced TNF-ɑ production (pg/ml), median (IQR)

Sample A (days 1–2)^a

204 (73, 411)

n = 50

176 (80, 396)

n = 22

Sample B (days 3–4)^a

209 (101, 358)

n = 40

232 (106, 716)

n = 16

Sample C (days 6–8)^a

320 (111, 414)

n = 17

225 (29, 358)

n = 10

Δ Sample A to B

0 (-130, 54)

20 (-23, 89)

Δ Sample A to C

16 (-112, 85)

29 (-85, 141)