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Table 2 Univariate logistic regression model to test association of AKI and initial serum chloride ([CL-]0), maximal serum chloride in first 48 hours ([Cl]max), and increase in serum chloride (Δ[Cl-] = [Cl-]max–[CL-]0)

From: Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients

Variable AKI stage 1 to 3 p AKI stage 2 and 3 p
Odds ratio (95 % CI) Odds ratio (95 % CI)
[CL-]0 1.01 (0.97–1.05) 0.478 0.99 (0.95–1.03) 0.562
[Cl-]max 1.14 (1.08–1.20) <0.001a 1.07 (1.02–1.12) 0.006a
Δ[CL-] 1.25 (1.16–1.36) <0.001a 1.14 (1.07–1.21) <0.001a
  1. AKI acute kidney injury, [Cl - ] 0 initial chloride concentration, [Cl - ] max maximal chloride concentration in the first 48 hours, Δ[Cl - ] increase in serum chloride, CI confidence interval
  2. aIndicates statistical significance, p <0.05