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Table 2 Univariate logistic regression model to test association of AKI and initial serum chloride ([CL-]0), maximal serum chloride in first 48 hours ([Cl–]max), and increase in serum chloride (Δ[Cl-] = [Cl-]max–[CL-]0)

From: Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients

Variable

AKI stage 1 to 3

p

AKI stage 2 and 3

p

Odds ratio (95 % CI)

Odds ratio (95 % CI)

[CL-]0

1.01 (0.97–1.05)

0.478

0.99 (0.95–1.03)

0.562

[Cl-]max

1.14 (1.08–1.20)

<0.001a

1.07 (1.02–1.12)

0.006a

Δ[CL-]

1.25 (1.16–1.36)

<0.001a

1.14 (1.07–1.21)

<0.001a

  1. AKI acute kidney injury, [Cl - ] 0 initial chloride concentration, [Cl - ] max maximal chloride concentration in the first 48 hours, Δ[Cl - ] increase in serum chloride, CI confidence interval
  2. aIndicates statistical significance, p <0.05